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Evaluation of pharmacological and toxic effects of ethanolic extract of radish pods in albino rabbits: A biochemical and histopathological study

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dc.contributor.author Younus, Ishrat
dc.contributor.author Siddiq, Afshan
dc.contributor.author Baig, Sadia Ghousia
dc.contributor.author Khan, Saira Saeed
dc.contributor.author Ahmed, Shadab
dc.contributor.author Osama, Muhammad
dc.date.accessioned 2022-12-07T07:54:43Z
dc.date.available 2022-12-07T07:54:43Z
dc.date.issued 2019-05-21
dc.identifier.citation Younus, I., Siddiq, A., Baig, S. G., Khan, S. S., Ahmed, S., & Osama, M. (2019). Evaluation of pharmacological and toxic effects of ethanolic extract of radish pods in albino rabbits: A biochemical and histopathological study. Pakistan Journal of Pharmaceutical Sciences, 32. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14849
dc.description.abstract Radish pods are known as vegetable eaten as a part of diet. Though the pharmacologic potential of radish has been well known but there are fewer reports regarding pharmacological and toxic effects of radish pods. On account of this reason, the current study was aimed to evaluate the pharmacological and toxic effects of ethanol extract of Raphanus caudatus (radish pods) in rabbits after 60 days of administration. The plant extract was administered in 250, 500 and 1000mg/kg doses and effect was observed on hepatic, renal, cardiac and lipid profile. The extract was found to be hepatoprotective, nephroprotective and cardioprotective. Also it showed hypocholestrolemic potential at 1000 mg/kg. However at higher doses the extract presented chronic gastritis. Conversely, no indication of histological alterations was seen in other vital organs such as liver, kidneys, heart. Thus there is critical requirement to identify toxic constituent/s inducing gastritis so that safety profile of the plant can be established for effective therapeutic use. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi en_US
dc.subject Radish pods en_US
dc.subject pharmacological effects en_US
dc.subject toxic effects en_US
dc.subject albino rabbits en_US
dc.title Evaluation of pharmacological and toxic effects of ethanolic extract of radish pods in albino rabbits: A biochemical and histopathological study en_US
dc.type Article en_US


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