dc.contributor.author |
Ayanniyi, Rashidat Oluwafunke |
|
dc.contributor.author |
Ojuade, Fatimoh Idowu |
|
dc.contributor.author |
Olumoh-Abdul, Hidayah |
|
dc.contributor.author |
Salawu, Kayode Muritala |
|
dc.contributor.author |
Olufadi-Ahmed, Haishat |
|
dc.contributor.author |
Adebisi-jose, Gbemisola Olusayo |
|
dc.date.accessioned |
2022-12-13T09:38:00Z |
|
dc.date.available |
2022-12-13T09:38:00Z |
|
dc.date.issued |
2019-01-01 |
|
dc.identifier.citation |
Ayanniyi, R. O., Ojuade, F. I., Olumoh-Abdul, H., Salawu, K. M., Olufadi-Ahmed, H., & Adebisi-Jose, G. O. (2019). Evaluation of anti-nociceptive and anti-inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth. Pakistan Journal of Pharmaceutical Sciences, 32. |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/14985 |
|
dc.description.abstract |
The leaf extract of Turraea vogelii Hook. f. ex. Benth. is used in ethnomedicine for the management of pain
and inflammation. Anti-nociceptive activity was determined using acetic acid-induced mouse writhing model. The antiinflammatory activity was investigated using in-vitro bovine serum albumin (BSA) denaturation assay and BSA-induced hind paw edema in rats. The extract (125-500 mg/kg) administered via the oral route produced a significant (p<0.005) inhibition of acetic acid-induced writhes. The percent inhibition of writhes for extract (500 mg/kg) and diclofenac (10 mg/kg) was 53.3 and 59.5% respectively. The methanol extract (10-6
-1.0 µg/mL) inhibited protein denaturation with IC50values of (1.06 × 10-3 µg/mL and 2.58 × 10-3 µg/mL) for extract and diclofenac respectively. Furthermore, the leaf extract (62.5 mg/kg) significantly (p<0.05) inhibited BSA-induced paw edema in rats. The methanol leaf extract of T. vogelii has anti-nociceptive and anti-inflammatory activities. These findings justify the use of the plant in traditional medicine for the management of pain and inflammation. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
en_US |
dc.subject |
Anti-nociceptive |
en_US |
dc.subject |
anti-inflammatory |
en_US |
dc.subject |
acetic acid |
en_US |
dc.subject |
bovine serum albumin |
en_US |
dc.subject |
Turraea vogelli |
en_US |
dc.title |
Evaluation of anti-nociceptive and anti-inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth |
en_US |
dc.type |
Article |
en_US |