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Evaluation of anti-nociceptive and anti-inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth

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dc.contributor.author Ayanniyi, Rashidat Oluwafunke
dc.contributor.author Ojuade, Fatimoh Idowu
dc.contributor.author Olumoh-Abdul, Hidayah
dc.contributor.author Salawu, Kayode Muritala
dc.contributor.author Olufadi-Ahmed, Haishat
dc.contributor.author Adebisi-jose, Gbemisola Olusayo
dc.date.accessioned 2022-12-13T09:38:00Z
dc.date.available 2022-12-13T09:38:00Z
dc.date.issued 2019-01-01
dc.identifier.citation Ayanniyi, R. O., Ojuade, F. I., Olumoh-Abdul, H., Salawu, K. M., Olufadi-Ahmed, H., & Adebisi-Jose, G. O. (2019). Evaluation of anti-nociceptive and anti-inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth. Pakistan Journal of Pharmaceutical Sciences, 32. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14985
dc.description.abstract The leaf extract of Turraea vogelii Hook. f. ex. Benth. is used in ethnomedicine for the management of pain and inflammation. Anti-nociceptive activity was determined using acetic acid-induced mouse writhing model. The antiinflammatory activity was investigated using in-vitro bovine serum albumin (BSA) denaturation assay and BSA-induced hind paw edema in rats. The extract (125-500 mg/kg) administered via the oral route produced a significant (p<0.005) inhibition of acetic acid-induced writhes. The percent inhibition of writhes for extract (500 mg/kg) and diclofenac (10 mg/kg) was 53.3 and 59.5% respectively. The methanol extract (10-6 -1.0 µg/mL) inhibited protein denaturation with IC50values of (1.06 × 10-3 µg/mL and 2.58 × 10-3 µg/mL) for extract and diclofenac respectively. Furthermore, the leaf extract (62.5 mg/kg) significantly (p<0.05) inhibited BSA-induced paw edema in rats. The methanol leaf extract of T. vogelii has anti-nociceptive and anti-inflammatory activities. These findings justify the use of the plant in traditional medicine for the management of pain and inflammation. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Anti-nociceptive en_US
dc.subject anti-inflammatory en_US
dc.subject acetic acid en_US
dc.subject bovine serum albumin en_US
dc.subject Turraea vogelli en_US
dc.title Evaluation of anti-nociceptive and anti-inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth en_US
dc.type Article en_US


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