dc.contributor.author |
Wu, Qi |
|
dc.contributor.author |
Zhao, Wanlong |
|
dc.contributor.author |
Chen, Gangling |
|
dc.contributor.author |
Su, Xue |
|
dc.contributor.author |
Li, Rong |
|
dc.date.accessioned |
2022-12-13T09:39:25Z |
|
dc.date.available |
2022-12-13T09:39:25Z |
|
dc.date.issued |
2019-01-04 |
|
dc.identifier.citation |
Wu, Q., Zhao, W., Chen, G., Su, X., & Li, R. (2019). Relevant effects of Taohong Siwu decoction on isolated rat aortic ring dependent on endothelium nitric oxide-cGMP pathway. Pakistan Journal of Pharmaceutical Sciences, 36(1SI), 261-269. |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/14988 |
|
dc.description.abstract |
Using rat thoracic aortic rings to test the relaxing effects of the 95% ethanol extract and aqueous extract of
Taohong Siwu decoction (THSW) on endothelium intact or endothelium removed aortic rings. Results showed that the 95% ethanol extract (0.1, 1, 10, 100, 1000 mg·L-1 ) and aqueous extract (0.1, 1, 10, 100, 1000 mg·L-1
) of THSW were able to relax the intact endothelium aortic rings pre-contracted by 10-6 mol·L-1 PE. 10-4 mol·L-1 L-NAME and 10-5 mol·L-1 methylene blue both were able to inhibit the relaxation other than indomethacin. For the endothelium removed aortic rings, potassium channel blocker 3×10-3mol·L-1 tetraethylammonium chloride and 10-5 mol·L-1 glibenclamide had no effect on the relaxation effects caused by the 95% ethanol extract and aqueous extract of THSW. It could be concluded that the 95% ethanol extract and aqueous extract of THSW relax blood vessel by endothelium-dependent way |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
en_US |
dc.subject |
Taohong Siwu |
en_US |
dc.subject |
thoracic aorta |
en_US |
dc.subject |
rat |
en_US |
dc.subject |
aortic ring |
en_US |
dc.subject |
relaxation |
en_US |
dc.title |
Relevant effects of Taohong Siwu decoction on isolated rat aortic ring dependent on endothelium nitric oxide-cGMP pathway |
en_US |
dc.type |
Article |
en_US |