PASTIC Dspace Repository

Relevant effects of Taohong Siwu decoction on isolated rat aortic ring dependent on endothelium nitric oxide-cGMP pathway

Show simple item record

dc.contributor.author Wu, Qi
dc.contributor.author Zhao, Wanlong
dc.contributor.author Chen, Gangling
dc.contributor.author Su, Xue
dc.contributor.author Li, Rong
dc.date.accessioned 2022-12-13T09:39:25Z
dc.date.available 2022-12-13T09:39:25Z
dc.date.issued 2019-01-04
dc.identifier.citation Wu, Q., Zhao, W., Chen, G., Su, X., & Li, R. (2019). Relevant effects of Taohong Siwu decoction on isolated rat aortic ring dependent on endothelium nitric oxide-cGMP pathway. Pakistan Journal of Pharmaceutical Sciences, 36(1SI), 261-269. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/14988
dc.description.abstract Using rat thoracic aortic rings to test the relaxing effects of the 95% ethanol extract and aqueous extract of Taohong Siwu decoction (THSW) on endothelium intact or endothelium removed aortic rings. Results showed that the 95% ethanol extract (0.1, 1, 10, 100, 1000 mg·L-1 ) and aqueous extract (0.1, 1, 10, 100, 1000 mg·L-1 ) of THSW were able to relax the intact endothelium aortic rings pre-contracted by 10-6 mol·L-1 PE. 10-4 mol·L-1 L-NAME and 10-5 mol·L-1 methylene blue both were able to inhibit the relaxation other than indomethacin. For the endothelium removed aortic rings, potassium channel blocker 3×10-3mol·L-1 tetraethylammonium chloride and 10-5 mol·L-1 glibenclamide had no effect on the relaxation effects caused by the 95% ethanol extract and aqueous extract of THSW. It could be concluded that the 95% ethanol extract and aqueous extract of THSW relax blood vessel by endothelium-dependent way en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Taohong Siwu en_US
dc.subject thoracic aorta en_US
dc.subject rat en_US
dc.subject aortic ring en_US
dc.subject relaxation en_US
dc.title Relevant effects of Taohong Siwu decoction on isolated rat aortic ring dependent on endothelium nitric oxide-cGMP pathway en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account