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Antidiabetic and antidyslipidemic potential of Echinops echinatus in rat models of type I and type II diabetes

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dc.contributor.author Chaudhry, Shafqat Rasul
dc.contributor.author Akram, Adnan
dc.contributor.author Aslam, Naveed
dc.contributor.author Wajid, Muhammad
dc.contributor.author Iqbal, Zafar
dc.contributor.author Nazir, Imran
dc.contributor.author Jabeen, Qaiser
dc.contributor.author Muhammad, Sajjad
dc.date.accessioned 2022-12-13T09:57:40Z
dc.date.available 2022-12-13T09:57:40Z
dc.date.issued 2019-03-05
dc.identifier.citation Chaudhry, S. R., Akram, A., Aslam, N., Wajid, M., Iqbal, Z., Nazir, I., ... & Muhammad, S. (2019). Antidiabetic and antidyslipidemic potential of Echinops echinatus in rat models of type I and type II diabetes. Pakistan journal of pharmaceutical sciences, 32(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15006
dc.description.abstract Echinops echinatus is traditionally an important plant that finds its extensive use as a diuretic, antiinflammatory, anti-pyretic, nerve tonic, abortifacient, aphrodisiac, antiasthmatic, and antidiabetic agent. The current study investigates protection against the hyperglycemia and dyslipidemia in alloxan-induced (type I diabetes) and fructose-fed insulin resistance (type II diabetes) models of diabetes treated with aqueous methanolic root extract of E. echinatus (Ee.Cr). Albino rats were treated orally with Ee.Cr at doses 100, 300 and 500mg/kg. The fasting blood glucose was measured by glucometer, while standard kits were used to determine the levels of serum total cholesterol, triglycerides and HDL. The administration of Ee.Cr significantly (P<0.001) reduced the FBG concentration in a dosedependent pattern in alloxan-induced and fructose-fed diabetic rats. The Ee.Cr also corrected the dyslipidemia associated with fructose and alloxan-induced diabetes by significantly (P<0.001) decreasing the concentration of serum total cholesterol, triglycerides, and LDL and by increasing HDL concentration. Ee.Cr also significantly (P<0.001) improved the glucose tolerance in fructose-fed rats. We conclude that Ee.Cr has antidiabetic and antidyslipidemic effects in both insulin-dependent alloxan-induced diabetes and fructose-induced insulin resistance diabetes rat models. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi en_US
dc.subject Antihyperglycemic en_US
dc.subject alloxan en_US
dc.subject antihyperlipidemic en_US
dc.subject insulin resistance en_US
dc.subject metabolic syndrome. en_US
dc.title Antidiabetic and antidyslipidemic potential of Echinops echinatus in rat models of type I and type II diabetes en_US
dc.type Article en_US


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