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Study on structural insight of the analysis of negative effects of opioids analgesics in naltrexone with TLR4 Mutations

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dc.contributor.author Tariq, Iqra
dc.contributor.author Farhan, Ali
dc.contributor.author Ashfaq, Usman Ali
dc.contributor.author Qasim, Muhammad
dc.contributor.author Rehman, Mahmood-ur
dc.contributor.author Humayun, Fahad
dc.contributor.author Shah, Masaoud
dc.contributor.author Munir, Anum
dc.contributor.author Masoud, Muhammad Shareef
dc.date.accessioned 2022-12-13T10:02:35Z
dc.date.available 2022-12-13T10:02:35Z
dc.date.issued 2019-01-16
dc.identifier.citation Tariq, I., Farhan, A., Ashfaq, U. A., Qasim, M., Humayun, F., Shah, M., ... & Masoud, M. S. (2019). Study on structural insight of the analysis of negative effects of opioids analgesics in naltrexone with TLR4 Mutations. Pakistan Journal of Pharmaceutical Sciences, 32. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15014
dc.description.abstract Chronic pain has been defined as the persistence that remained for more than three months. The extent of previous time duration with the normal time of natural healing phase becomes poor and results in reduced life quality and morbidity. Opioids are well recognized therapy for pain management and the clinical prescriptions based on opioids have been defined with increasing implicating behavior among patients suffering with chronic pain. The association between the pain and immunity has long been established since the involvement of interleukin-1ß (IL-1ß) in sickness that is considered with the induced hyperalgesia. In the context of pharmacodynamics Toll like receptors (TLRs) are involved in the negative effects of opioids as analgesics. The soluble factors released by immune cells as well as from the disruptive cells bind to TLRs. This binding leads the pre and post-synaptic ends on endothelial and microglial cells that exhibit the activation of complex inhibitory and excitatory process at the synapses site. In TLRs, TLR4 is mostly reported that is strongly associated in specifically in areas of T cells and macrophages. The current study is designed to investigate the structural insights of the opioids and TLR4 interactions by using computational approach in the aspect of recognizing the chemical combinatorial factors that are involved in the pain management. This study targets that how opioids interact with TLR4 and the process of chemical interaction that leads to negative effects of opioids at neuroimmune interface as well as to investigate the extent of particular naltrexone that mediates with the negative effects of opioids. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Naltrexone en_US
dc.subject TLR4 en_US
dc.subject opioids en_US
dc.subject analgesics en_US
dc.title Study on structural insight of the analysis of negative effects of opioids analgesics in naltrexone with TLR4 Mutations en_US
dc.type Article en_US


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