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Thiosemicarbazone and thiazolylhydrazones of 1-indanone: As a new class of nonacidic anti-inflammatory and antiplatelet aggregation agents

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dc.contributor.author Nazim, Urooj
dc.contributor.author Ahmed, Mansoor
dc.contributor.author Ali, Basharat
dc.contributor.author Khan, Khalid Mohammed
dc.contributor.author Ali, Mohsin
dc.contributor.author Kobarfard, Farzad
dc.contributor.author Arshia, Arshia
dc.contributor.author Ayatollahi, S Abdul Majid
dc.contributor.author Hassan, Amir
dc.contributor.author Jabeen, Almas
dc.contributor.author Faheem, Ayesha
dc.date.accessioned 2022-12-13T10:11:46Z
dc.date.available 2022-12-13T10:11:46Z
dc.date.issued 2019-01-03
dc.identifier.citation Nazim, U., Ahmed, M., Ali, B., Khan, K. M., Ali, M., Kobarfard, F., ... & Faheem, A. (2019). Thiosemicarbazone and thiazolylhydrazones of 1-indanone: As a new class of nonacidic anti-inflammatory and antiplatelet aggregation agents. Pakistan Journal of Pharmaceutical Sciences, 32(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15032
dc.description.abstract This research based on the anti-inflammatory and antiplatelet aggregation properties of some new thiazolyl hydrazone derivatives of 1-indanone. In this regard a thiosemicabazone and twelve thiazolyl derivatives of 1-indanone have been synthesized. Out of these synthetic compounds seven derivatives 1-3, 6, 11-13 exhibited varying degree of anti-inflammatory action with IC50 esteems going from 5.1±1.3 - 78.8±4.6µM/mL. Compound 1 (IC50 =5.1±1.9µM) displayed potent result than standard ibuprofen (IC50 = 11.2±1.9 µM). In antiplatelet aggregation assay, five compounds 1, 5, 6, 8 and 11 were observed to be dynamic with IC50 esteems observed in the range of 38.34-255.7±4.1µM, whereas, aspirin (IC50 = 30.3±2.6 µM) was used as standard. However, compound 11 was found to be good active for both antiinflammatory and antiplatelet aggregation activities (IC50 = 13.9±4.9µg/mL) (IC50 = 38.60±3.1µM), respectively. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject 1-Indanone en_US
dc.subject thiosemicarbazone en_US
dc.subject thiazole en_US
dc.subject antiplatelet aggregation en_US
dc.subject anti-inflammatory. en_US
dc.title Thiosemicarbazone and thiazolylhydrazones of 1-indanone: As a new class of nonacidic anti-inflammatory and antiplatelet aggregation agents en_US
dc.type Article en_US


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