dc.contributor.author |
Nazim, Urooj |
|
dc.contributor.author |
Ahmed, Mansoor |
|
dc.contributor.author |
Ali, Basharat |
|
dc.contributor.author |
Khan, Khalid Mohammed |
|
dc.contributor.author |
Ali, Mohsin |
|
dc.contributor.author |
Kobarfard, Farzad |
|
dc.contributor.author |
Arshia, Arshia |
|
dc.contributor.author |
Ayatollahi, S Abdul Majid |
|
dc.contributor.author |
Hassan, Amir |
|
dc.contributor.author |
Jabeen, Almas |
|
dc.contributor.author |
Faheem, Ayesha |
|
dc.date.accessioned |
2022-12-13T10:11:46Z |
|
dc.date.available |
2022-12-13T10:11:46Z |
|
dc.date.issued |
2019-01-03 |
|
dc.identifier.citation |
Nazim, U., Ahmed, M., Ali, B., Khan, K. M., Ali, M., Kobarfard, F., ... & Faheem, A. (2019). Thiosemicarbazone and thiazolylhydrazones of 1-indanone: As a new class of nonacidic anti-inflammatory and antiplatelet aggregation agents. Pakistan Journal of Pharmaceutical Sciences, 32(1). |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/15032 |
|
dc.description.abstract |
This research based on the anti-inflammatory and antiplatelet aggregation properties of some new thiazolyl
hydrazone derivatives of 1-indanone. In this regard a thiosemicabazone and twelve thiazolyl derivatives of 1-indanone have been synthesized. Out of these synthetic compounds seven derivatives 1-3, 6, 11-13 exhibited varying degree of anti-inflammatory action with IC50 esteems going from 5.1±1.3 - 78.8±4.6µM/mL. Compound 1 (IC50 =5.1±1.9µM) displayed potent result than standard ibuprofen (IC50 = 11.2±1.9 µM). In antiplatelet aggregation assay, five compounds 1, 5, 6, 8 and 11 were observed to be dynamic with IC50 esteems observed in the range of 38.34-255.7±4.1µM, whereas, aspirin (IC50 = 30.3±2.6 µM) was used as standard. However, compound 11 was found to be good active for both antiinflammatory and antiplatelet aggregation activities (IC50 = 13.9±4.9µg/mL) (IC50 = 38.60±3.1µM), respectively. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
en_US |
dc.subject |
1-Indanone |
en_US |
dc.subject |
thiosemicarbazone |
en_US |
dc.subject |
thiazole |
en_US |
dc.subject |
antiplatelet aggregation |
en_US |
dc.subject |
anti-inflammatory. |
en_US |
dc.title |
Thiosemicarbazone and thiazolylhydrazones of 1-indanone: As a new class of nonacidic anti-inflammatory and antiplatelet aggregation agents |
en_US |
dc.type |
Article |
en_US |