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Pumpkin (Cucurbita moschata) against Aspergillus flavus and aflatoxin B1 induced lung cyto-morphological damage in rats

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dc.contributor.author Saddiq, Amna Ali Nasser
dc.contributor.author Awedh, Mohammad Hamza
dc.date.accessioned 2022-12-13T10:13:15Z
dc.date.available 2022-12-13T10:13:15Z
dc.date.issued 2019-03-15
dc.identifier.citation Saddiq, A. A. N., & Awedh, M. H. (2019). Pumpkin (Cucurbita moschata) against Aspergillus flavus and aflatoxin B1 induced lung cyto-morphological damage in rats. Pak. J. Pharm. Sci, 32(2), 575-579. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15034
dc.description.abstract The protective efficacy of pumpkin (Cucurbita moschata) fruit aqueous extract against either aflatoxin B1 (AFB1) toxicity and Aspergillus flavus fungus infection induced lung histolomorphological damage in rats was investigated. AFB1 and A. flavus were administered intraperitoneally (0.2mg/Kg body weight) for 15 successive days. The result demonstrated that intoxication of rats with AFB1 induced lung damage as observed by alveolar hyperplasia, pulmonary hemorrhage and fibrosis. Infection with A. flavus also showed damaging impact on the rat lung as observed by fibrosis of bronchioles and alveolar hyperplasia. Oral co-administration of aqueous extract of pumpkin fruits (1.0 mg / kg of body weight) to either rat groups intoxicated with AFB1 or infected with A. flavus for 20 consecutive days showed more or less normal histological structure of rat lungs. In conclusion, aqueous extract of pumpkin fruits has a protective role against AFB1 or A. flavus induced lung damage which may be related to the antioxidant constituents of the plant extract. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi en_US
dc.subject Aspergillus flavus en_US
dc.subject aflatoxin B en_US
dc.subject lung damage en_US
dc.title Pumpkin (Cucurbita moschata) against Aspergillus flavus and aflatoxin B1 induced lung cyto-morphological damage in rats en_US
dc.type Article en_US


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