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Healing effects of Pergularia tomentosa L., a native medicinal plant in Bushehr province, Iran on burn, in animal model

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dc.contributor.author Farzadinia, Parviz
dc.contributor.author Mohebbi, Gholamhossein
dc.contributor.author Bargahi, Afshar
dc.contributor.author Akbarzadeh, Samad
dc.contributor.author Nabipour, Iraj
dc.contributor.author Abdi, Mohammadreza
dc.contributor.author Hasanpour, Zeynab
dc.contributor.author Alipour, Zahra
dc.contributor.author Daneshi, Adel
dc.date.accessioned 2022-12-13T10:13:44Z
dc.date.available 2022-12-13T10:13:44Z
dc.date.issued 2019-01-04
dc.identifier.citation Farzadinia, P., Mohebbi, G., Bargahi, A., Akbarzadeh, S., Nabipour, I., Abdi, M., ... & Daneshi, A. (2019). Healing effects of Pergularia tomentosa L., a native medicinal plant in Bushehr province, Iran on burn, in animal model. Pakistan Journal of Pharmaceutical Sciences, 32(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15035
dc.description.abstract Burn injury is one of the most destructive events in the world. The Pergularia tomentosa L. is a medicinal plant that traditionally, applies for treatment of burning, in Bushehr province, Iran. Various bioactive compounds such as steroid glycosides, tannins, various vitamins, saponins, cardenolides and anthraquinones were identified into extract of the plant, which can be effective in burn wound healing. Twenty-one rats weighting every one 200±5 grams were divided equally into three groups. The second-degree burning induced on all groups. One of groups did not receive any treatment (The control group) and was treated locally with saline and eucerin. The Second group received the P. tomentosa L. as a topical ointment, and the third group received locally, a thin layer of silver sulfadiazine ointment 3% after washing the wound with saline. Afterward treatment period, the microscopic slides from histological sections were prepared. At that point, amounts of the fibroblast cells, blood vessels, wound area, necrotic tissues, and diameter of epidermis rate of wound healing were determined. Also the exterior status of wound in different days was considered. Results obtained from current study have revealed that the extract of P. tomentosa L. can significantly, cause qualitative and quantitative acceleration in healing of second degree burn wounds, due to their bioactive and vasoactive properties. In conclusion the P. tomentosa L. can is used as an overborne medicine with lower cost and side effect than the similar chemical medicines. Although, the further studies are needed on these plants, due to their some toxic effects. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Pergularia tomentosa L en_US
dc.subject burn injury en_US
dc.subject therapeutic effect en_US
dc.title Healing effects of Pergularia tomentosa L., a native medicinal plant in Bushehr province, Iran on burn, in animal model en_US
dc.type Article en_US


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