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Protective effects of vitamin D and losartan in complete Freund's adjuvant-induced arthritis in rats

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dc.contributor.author Gaafar, Ahmed G
dc.contributor.author youssef, Amira M Abo-
dc.contributor.author Khalaf, Marwa M
dc.contributor.author saif, Ali A Abo-
dc.date.accessioned 2022-12-13T10:15:57Z
dc.date.available 2022-12-13T10:15:57Z
dc.date.issued 2019-03-17
dc.identifier.citation Gaafar, A. G., Abo-Youssef, A. M., Khalaf, M. M., & Abo-Saif, A. A. (2019). Protective effects of vitamin D and losartan in complete Freund's adjuvant-induced arthritis in rats. Pakistan Journal of Pharmaceutical Sciences, 32(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15037
dc.description.abstract The current study was designed to explore the protecting effects of vitamin D and losartan in treatment of rheumatoid arthritis (RA). Animals were allotted to five groups: Group I received vehicles only (vehicle control). Group II was administered complete Freund’s adjuvant (CFA) and did not receive any medication. The remaining three groups (III, IV, V) were given CFA followed by treatment with leflunomide, vitamin D or losartan, respectively for two weeks. Compelling increment in tumor necrosis factor (TNF-α), interleukin 6 (IL-6), rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), malondialdehyde (MDA) level, white blood cells (WBCs), total cholesterol (TC) and triglycerides (TGs) was revealed in arthritic rats. This was associated with marked decline in glutathione (GSH) level, red blood cells (RBCs), hemoglobin (Hb), Platelets (Plts), hematocrit (Hct) and high density lipoprotein cholesterol (HDL). vitamin D or losartan significantly decreased TNF α, IL-6, RF, ESR, MDA, TC, TGs, WBCs and significantly increased RBCs, Hb, Hct, Plts and HDL. It could be concluded that vitamin D and losartan are able to repress the alterations associated with adjuvant-induced arthritis (AIA). This preserving effect might be partially attributed to antiarithritic, hypolipidemic and antianemic properties en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi en_US
dc.subject Complete Freund’s adjuvan en_US
dc.subject leflunomide en_US
dc.subject losartan en_US
dc.subject rats en_US
dc.subject rheumatoid arthritis en_US
dc.subject rheumatoid factor en_US
dc.subject vitamin D en_US
dc.title Protective effects of vitamin D and losartan in complete Freund's adjuvant-induced arthritis in rats en_US
dc.type Article en_US


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