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Supplementation of Cannabis sativa L. leaf powder accelerates functional recovery and ameliorates haemoglobin level following an induced injury to sciatic nerve in mouse model

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dc.contributor.author Aziz, Nimra
dc.contributor.author Rasul, Azhar
dc.contributor.author Ahmad Malik, Shoaib
dc.contributor.author Anwar, Haseeb
dc.contributor.author Imran, Ali
dc.contributor.author Razzaq, Aroona
dc.contributor.author Shaukat, Arslan
dc.contributor.author Shahid Kamran, Syed Kashif
dc.contributor.author Gonzalez de Aguilar, Jose-Luis
dc.contributor.author Sun, Tao
dc.contributor.author Hussain, Ghulam
dc.date.accessioned 2022-12-13T10:16:30Z
dc.date.available 2022-12-13T10:16:30Z
dc.date.issued 2019-03-20
dc.identifier.citation Aziz, N., Rasul, A., Malik, S. A., Anwar, H., Imran, A., Razzaq, A., ... & Hussain, G. (2019). Supplementation of Cannabis sativa L. leaf powder accelerates functional recovery and ameliorates haemoglobin level following an induced injury to sciatic nerve in mouse model. Pakistan journal of pharmaceutical sciences, 32. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15038
dc.description.abstract Peripheral nerve injury is a common condition with a multitude of signs and symptoms. The major consequence of injury is limited physical activity. Presently, we are lacking effective therapies for PNI and it is need of the hour is to explore potential remedies for the recovery of functional loss. Here, we have investigated the role of crude Cannabis sativa L. leaf powder in promoting functions recovery, in mouse model subjected to a traumatic sciatic nerve injury. A dose of 200mg/kg of the body weight per day was administered orally from the day of nerve crush till the end of the experiment. The motor functions were evaluated by measuring sciatic functional index, muscle grip strength and muscle mass; whereas the sensory functions were assessed by hotplate test. The haematology and serum analyses were carried out to estimate the effect of treatment on the systemic index and oxidative stress. The gain of motor functions was significantly improved and was early noticed in the treated mice. Restoration of muscle mass and elevated haemoglobin level were statistically significant in the treatment group. This study indicates that Cannabis sativa L. supplementation accelerates the motor functions recovery after nerve compression injury. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Peripheral nerve injury en_US
dc.subject functional recovery en_US
dc.subject Cannabis sativa L en_US
dc.subject oxidative stress en_US
dc.subject haemoglobin en_US
dc.title Supplementation of Cannabis sativa L. leaf powder accelerates functional recovery and ameliorates haemoglobin level following an induced injury to sciatic nerve in mouse model en_US
dc.type Article en_US


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