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Preventive and therapeutic effects of aqueous extract of Spinacia oleracea on Psoriatic patches in albino rats

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dc.contributor.author Siddiqui, Durr-e-Shahwar
dc.contributor.author Afroz, Syeda
dc.contributor.author Khan, Rafeeq Alam
dc.date.accessioned 2022-12-13T10:16:55Z
dc.date.available 2022-12-13T10:16:55Z
dc.date.issued 2019-01-06
dc.identifier.citation Durr-e-Shahwar Siddiqui, S. A., & Khan, R. A. (2019). Preventive and therapeutic effects of aqueous extract of Spinacia oleracea on psoriatic patches in albino rats. Pak. J. Pharm. Sci, 32(1), 035-042. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15039
dc.description.abstract Psoriasis has become a topic of global concern because of consistency in its prevalence according to Global Report on Psoriasis 2016, however, till date no therapy has provided complete cure of this disease and no useful measure was discovered to prevent it or eliminate the risk of its relapse. Hence, the present study was designed to evaluate anti-psoriatic effects of Spinacia oleracea due to its anti-inflammatory, anti-oxidant, anti-proliferative and skinstrengthening contents. Psoriasis was induced by oral potassium iodide solution which was then determined by two methods i.e. percentage reduction in psoriatic patch size and psoriasis area and severity index (PASI) score to measure the decrease in severity. Twenty albino rats were used in each method, grouped as standard, curative, preventive and control with five rats in each group. Therapeutic and preventive doses for S. oleracea in both the methods were calculated according to daily intake guidelines of National Cancer Institute, USA, and German Nutrition Society, DGE guidelines respectively with slight modification. Methotrexate was used as standard drug along with folic acid to avoid toxic effects. This study reveals that S. oleracea has both therapeutic and preventive effects. It may be concluded that S. oleracea can be effectively used as sole therapy for psoriasis. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Psoriasis en_US
dc.subject Spinacia oleracea en_US
dc.subject erythema en_US
dc.subject induration en_US
dc.subject desquamation. en_US
dc.title Preventive and therapeutic effects of aqueous extract of Spinacia oleracea on Psoriatic patches in albino rats en_US
dc.type Article en_US


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