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Stability and in vitro release kinetic studies of cinitapride (1mg) mouth dissolving tablets

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dc.contributor.author Bushra, Rabia
dc.contributor.author Ghayas, Sana
dc.contributor.author Ali, Huma
dc.contributor.author Zafar, Farya
dc.contributor.author Shafiq, Yousra
dc.contributor.author Ahmed, Kamran
dc.date.accessioned 2022-12-14T03:30:56Z
dc.date.available 2022-12-14T03:30:56Z
dc.date.issued 2019-03-20
dc.identifier.citation Bushra, R., Ghayas, S., Ali, H., Zafar, F., Shafiq, Y., & Ahmed, K. (2019). Stability and in vitro release kinetic studies of cinitapride (1mg) mouth dissolving tablets. Pakistan Journal of Pharmaceutical Sciences, 32(SI2), 793-799. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15042
dc.description.abstract Cinitapride has been widely given in gastro-esophageal reflux disease (GERD) and dysphagia due to irregularities of GI motilities. Mouth dissolving tablets were prepared for rapid availability and action of drug. Multipoint dissolution studies were conducted in 0.1 N HCl solution of pH 1.2 and phosphate buffer of pH 4.5 and 6.8. Drug release profile showed higher liberation of cinitapride at lower pH then basic medium (<80%). Formulation containing crospovidone (10%) was found to be optimized trial having excellent quality pharmaceutical attributes. The lowest AIC, highest MSC and regression (> 0.9) values were observed for Weibull kinetics in all dissolution medium reflecting the excellent model fitting for the present study. Accelerated stability testing data showed excellent results of drug assay (>99%) along with physical characteristics indicating the absence of drug degradation as well excipient interaction. The estimated shelf life period of various optimized trial formulations was found in between 33 to 41 months. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Cinitapride en_US
dc.subject tablets, mouth dissolving tablets en_US
dc.subject biowaiver, in vitro kinetics en_US
dc.subject stability testing en_US
dc.title Stability and in vitro release kinetic studies of cinitapride (1mg) mouth dissolving tablets en_US
dc.type Article en_US


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