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Comparison of neuropharmacological activities of methanolic extracts of Cuminum nigrum (Linn.) and Centratherum anthelminticum (Linn.) in mice

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dc.contributor.author Mahmood, Raana
dc.contributor.author Ikram, Rahila
dc.contributor.author Rizwani, Ghazala H
dc.contributor.author Khatoon, Humera
dc.date.accessioned 2022-12-14T03:57:27Z
dc.date.available 2022-12-14T03:57:27Z
dc.date.issued 2019-01-12
dc.identifier.citation Mahmood, R., Ikram, R., Rizwani, G. H., & Khatoon, H. (2019). Comparison of neuropharmacological activities of methanolic extracts of Cuminum nigrum (Linn.) and Centratherum anthelminticum (Linn.) in mice. Pakistan Journal of Pharmaceutical Sciences, 32(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15050
dc.description.abstract The study is conducted to observe and investigate the effects of oral dosing of methanolic extracts of Cuminum nigrum (L) and Centratherum anthelminticum (L) on neuropharmacological activities of mice. Methanolic extracts of Cuminum nigrum (L) and Centratherum anthelminticum (L) were soluble in Dimethyl sulphoxide (DMSO) i.e. an organic solvent, so it is used in this study. Screening for anxiolytic and antidepressant effects were performed using open field test, head dip test, stationary rod test, cage crossing test, light and dark box and swimming– induced depression test. Thirty animals were divided into three groups of 10 animals each and numbered as 1 (control, on DMSO), 2(on methanolic extract of Cuminum nigrum (L), 3 (on methanolic extract of Centratherum anthelminticum (L). The extracts and DMSO were administered orally for 60 days. Any possible change in animal behavior was evaluated on day 15, 30 and 60 of dosing. The groups 2 and 3 showed significant increase (p<0.001, p<0.01) in open field activity and light and dark box test respectively, while significantly decreased activity was observed in head dip and cage crossing activity (p<0.01) after 60 days of dosing. Based on above findings, it is suggested that the extracts of Centratherum anthelminticum (L) and Cuminum nigrum (L) have antidepressant and anxiolytic potential with sedative effects. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Antidepressant en_US
dc.subject anxiolytic en_US
dc.subject Centratherum anthelminticum (L) en_US
dc.subject Cuminum nigrum (L) en_US
dc.subject neuropharmacological en_US
dc.subject sedative en_US
dc.title Comparison of neuropharmacological activities of methanolic extracts of Cuminum nigrum (Linn.) and Centratherum anthelminticum (Linn.) in mice en_US
dc.type Article en_US


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