PASTIC Dspace Repository

The physiological and lifespan alterations in Caenorhabditis elegans exposed to different dosages of melatonin

Show simple item record

dc.contributor.author Omer Karadas
dc.contributor.author Necati Ozpinar
dc.contributor.author Elif Bilgic
dc.contributor.author Fatih Ozcelik
dc.contributor.author Sema Karada
dc.date.accessioned 2022-12-14T04:06:40Z
dc.date.available 2022-12-14T04:06:40Z
dc.date.issued 2019-03-21
dc.identifier.citation Karadas, O., Ozpinar, N., Bilgic, E., Ozcelik, F., & Karadas, S. (2019). The physiological and lifespan alterations in Caenorhabditis elegans exposed to different dosages of melatonin. Pakistan Journal of Pharmaceutical Sciences, 32(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15054
dc.description.abstract Aging is a process that begins at birth and ends with death. This process is accompanied by environmental effects, which cause structural and functional changes in cells and tissues. With regards to healthy aging, melatonin significantly extends lifespan. This study aims to show the anti-aging effects of melatonin on lifespan by a model organism called Caenorhabditis elegans. The nematode strain N2 (wild-type) was acquired, and E. coli OP50 was used in the study. Worms were grouped into a control group (n=100), and six experimental groups (group 1, 2, 3, 4, 5 and group 6) (n=100 in each of them). Interventions were made by exposing Caenorhabditis elegans to various dosages of melatonin and follow up was made for 21 days. The survey of Caenorhabditis elegans, which depends on time and dosage as the main outcome measures, was examined microscopically. Different dosages of melatonin affected the lifespan and morphology of Caenorhabditis elegans. Melatonin might be used in the prevention of aging. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi en_US
dc.subject Melatonin en_US
dc.subject Caenorhabditis elegans en_US
dc.subject aging. en_US
dc.title The physiological and lifespan alterations in Caenorhabditis elegans exposed to different dosages of melatonin en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account