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Neuroprotective evaluation of Tribulus terrestris L. in aluminum chloride induced Alzheimer’s disease

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dc.contributor.author Chauhdary, Zunera
dc.contributor.author Saleem, Uzma
dc.contributor.author Ahmad, Bashir
dc.contributor.author Shah, Shahid
dc.contributor.author Shah, Muhammad Ajmal
dc.date.accessioned 2022-12-14T04:09:02Z
dc.date.available 2022-12-14T04:09:02Z
dc.date.issued 2019-03-20
dc.identifier.citation Chauhdary, Z., Saleem, U., Ahmad, B., Shah, S., & Shah, M. A. (2019). Neuroprotective evaluation of Tribulus terrestris L. in aluminum chloride induced Alzheimer's disease. Pakistan journal of pharmaceutical sciences, 32. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15055
dc.description.abstract Tribulus terrestris (T.T) is enriched with steroidal saponins and flavonoids which have neuroprotective effect. The study was aimed to explore the potential of T.T methanol extract (T.T ME) for anti-Alzheirmer activity along with its safety evaluation. Plant was characterized by physicochemical, phytochemical and GCMS analyses whereas acute oral toxicity (OECD 425) was performed for safety evaluation. AlCl3 induced Alzheimer’s disease rat model was used for anti-alzheirmer activity. T.T ME was given orally at 100, 300 and 1000 mg/kg doses for 21 days and behavioral parameters were observed on 22nd study day. Physicochemical parameters were in permissible limits. GCMS analysis showed eight different compounds and benzene dicarboxylic acid showed maximum % peak area (64.19). No mortality was noted in acute toxicity study. Behavioral studies showed highly significant (p<0.001) improvement in T.T ME treated groups. Antioxidant enzymes and acetylcholinesterase levels were significantly (p<0.05) improved on treatment with T.T ME. Histopathological analysis indicated that neurofibrillary tangles were significantly improved in T.T ME treated groups. Biochemical and behavioral results suggested that T.T contained lead compounds which are effective in the treatment of Alzheimer disease. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Aluminum chloride en_US
dc.subject anti-Alzheimer activity en_US
dc.subject Tribulus terrestris en_US
dc.title Neuroprotective evaluation of Tribulus terrestris L. in aluminum chloride induced Alzheimer’s disease en_US
dc.type Article en_US


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