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Antimicrobial, antiquorum sensing and antiproliferative activities of sesquiterpenes from Costus speciosus rhizomes

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dc.contributor.author Ibrahim, Sabrin Ragab Mohamed
dc.contributor.author El-Shaer, Nagwa Salah Al-Din Ahmed
dc.contributor.author Asfour, Hani Zakaria
dc.contributor.author Elshali, Khalid Zaki
dc.contributor.author Shaaban, Mona Ibrahim Awad
dc.contributor.author Al-Attas, Ahmed Alawi Mohsen
dc.contributor.author Mohamed, Gamal Abd Allah
dc.date.accessioned 2022-12-14T04:15:08Z
dc.date.available 2022-12-14T04:15:08Z
dc.date.issued 2019-01-16
dc.identifier.citation Asfour, H. Z., Elshali, K. Z., Shaaban, M. I. A., Al-Attas, A. A. M., & Mohamed, G. A. A. (2019). Antimicrobial, antiquorum sensing and antiproliferative activities of sesquiterpenes from Costus speciosus rhizomes. Pak. J. Pharm. Sci, 32(1), 109-115. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15059
dc.description.abstract The quorum sensing inhibitory (QSI) and antimicrobial potentials of the total methanol extract (TME) and different extractives as well as the sesquiterpenes: dehydrodihydrocostus lactone (1), dehydrocostus lactone (2), arbusculin A (3), santamarine (4), reynosin (5), and specioic acid (6) isolated from Costus speciosus rhizomes were evaluated. The CHCl3:EtOAc (1:1), EtOAc, and TME fractions exhibited potent antibacterial activity toward B. cereus with inhibition zone diameter 13 mm. While the CHCl3 fraction showed strong activity towards S. aureus and B. cereus with inhibition zone diameter 11 and 19 mm, respectively. Moreover, the TME and CHCl3 fractions have strong activity towards C. albicans with inhibition zone diameter 15 and 12 mm, respectively. Compound 5 showed prominent activity towards B. cereus (MIC 385 µg/mL). However, 6 exhibited significant activity with MIC values of 150, 400, and 550 µg/mL towards S. aureus, E. coli, and B. cereus, respectively. Moreover, it showed potent antifungal effect towards C. albicans (MIC 320 µg/mL). Most of the tested fractions had QSI activity against C. violaceum. Only compound 6 exhibited moderate QSI effect with disappearance of violet pigment. In addition, compounds 1-6 were evaluated for their in vitro antiproliferative activity towards KB, BT-549, SK-MEL, and SKOV-3 cancer cell lines. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Costus speciosus en_US
dc.subject sesquiterpenes en_US
dc.subject antimicrobial en_US
dc.subject antiquorum sensing en_US
dc.subject antiproliferative en_US
dc.title Antimicrobial, antiquorum sensing and antiproliferative activities of sesquiterpenes from Costus speciosus rhizomes en_US
dc.type Article en_US


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