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Formulation development and in-vitro evaluation of fast dispersible, taste masked Aceclofenac compacted pellets

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dc.contributor.author Yasmin, Riffat
dc.contributor.author Shoaib, Muhammad Harris
dc.contributor.author Qazi, Faaiza
dc.contributor.author Nasiri, Muhammad Iqbal
dc.contributor.author Ali, Tariq
dc.contributor.author Zafar, Farya
dc.date.accessioned 2022-12-14T04:19:20Z
dc.date.available 2022-12-14T04:19:20Z
dc.date.issued 2019-01-17
dc.identifier.citation Yasmin, R., Shoaib, M. H., Qazi, F., Nasiri, M. I., Ali, T., Ali, H., & Zafar, F. (2019). Formulation development and in-vitro evaluation of fast dispersible, taste masked Aceclofenac compacted pellets. Pakistan Journal of Pharmaceutical Sciences, 32(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15062
dc.description.abstract The objective of this study was to develop Aceclofenac fast dispersible compacted pellets with improved taste and fast drug release. Pellets were prepared by extrusion-spheronization technique followed by direct compression to make compacted pellets. Formulations were comprised of sucrose, mannitol, ac-di-sol, aspartame, pine apple flavor and magnesium stearate. A mixture of distilled water and isopropyl alcohol (1:1) was used for wet massing. The effect of acdi-sol on the drug release pattern was examined and dissolution profile comparison was established. All formulations followed First order and Weibull models and f2 values indicated dissimilarity with the marketed immediate release product. Taste of compacted pellets was evaluated by a panel of 12 human volunteers. Formulation P5 was found to be an optimized formulation due to satisfactory quality attributes. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Extrusion-spheronization en_US
dc.subject fast dispersible compacted pellets en_US
dc.subject Aceclofenac, direct compression en_US
dc.title Formulation development and in-vitro evaluation of fast dispersible, taste masked Aceclofenac compacted pellets en_US
dc.type Article en_US


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