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Frequency of aspirin non responsiveness in patients of ischemic heart disease

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dc.contributor.author Rizvi, Syed Khizar Abbas
dc.contributor.author Mohsin, Shahida
dc.contributor.author Saeed, Tahir
dc.contributor.author Ahmad, Saeed
dc.date.accessioned 2022-12-14T04:35:26Z
dc.date.available 2022-12-14T04:35:26Z
dc.date.issued 2019-03-24
dc.identifier.citation Rizvi, S. K. A., Mohsin, S., Saeed, T., & Ahmad, S. (2019). Frequency of aspirin non responsiveness in patients of ischemic heart disease. Pakistan Journal of Pharmaceutical Sciences, 32(2), 647-651. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15071
dc.description.abstract Aspirin is widely used as an antiplatelet agent. Many patients have been noticed with recurrence of major ischemic events in- spite of antiplatelet therapy. The objective of this study was to determine frequency of aspirin nonresponsiveness /resistance in patients of ischemic heart disease. Seventy one patients of IHD were selected from outpatient department of Punjab Institute of Cardiology Lahore. Whole Blood Platelet aggregation studies were performed on Diamed Impact R. Aspirin response assay was performed with DiaChidon (Arachidoinc Acid 16mmol/L). Non responders to aspirin were assessed on the basis of software generated results: Surface covered (SC) ≥2.5% was considered as response to aspirin and SC <2.5% was considered as no response (or resistance) to Aspirin. Chi-square test was applied to measure statistical significance. Non-response to Aspirin was observed in 11% (8 out of 71). There was significant association (p=0.045) between resistance to aspirin and Diabetes mellitus. Treatment resistance was also significantly associated with female gender (p=0.015). We concluded that non response to Aspirin is seen in significant number of patients of IHD. Diabetes mellitus and female gender are strong risk factors of developing failure to aspirin therapy. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi en_US
dc.subject Ischemic heart disease en_US
dc.subject platelet aggregatio en_US
dc.subject aspirin en_US
dc.subject non response en_US
dc.title Frequency of aspirin non responsiveness in patients of ischemic heart disease en_US
dc.type Article en_US


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