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Evaluation of anticonvulsant and antiepileptogenic activity of Euphorbia nivulia in PTZ-induced kindling model of epilepsy in mice

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dc.contributor.author Rehman, Agha Habibur
dc.contributor.author Sharar, Shakir D Al
dc.contributor.author Ahmad, Mahmood
dc.contributor.author Akhtar, Muhammad
dc.contributor.author Khan, Younus
dc.contributor.author Ashra, Muhammad Nadeem
dc.date.accessioned 2022-12-14T04:44:09Z
dc.date.available 2022-12-14T04:44:09Z
dc.date.issued 2019-03-28
dc.identifier.citation Rehman, A. H., Al Sharari, S. D., Ahmad, M., Akhtar, M., Khan, Y., & Ashraf, M. N. (2019). Evaluation of anticonvulsant and antiepileptogenic activity of Euphorbia nivulia in PTZ-induced kindling model of epilepsy in mice. Pakistan Journal of Pharmaceutical Sciences, 32(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15083
dc.description.abstract Epilepsy rema ins a major chronic neurological disorder with significantly higher refractory seizure rate. Based on the folk medicine literature, we explored the anticonvulsant and antiepileptogenic activity of aqueous ethanolic extracts of Fu maria indica, Euphorbia lactea, Euphorbia helioscopia, Neurada procumbens, and Euphorbia nivulia. The acute anticonvulsant activity of the extracts was determined at different concentrations in different groups of Swiss albino mice. Among all the materials tested, the ethanolic extracts of Euphorbia nivulia (eth-EN) alone was found to exhibit concentration-dependent anticonvulsant effects when evaluated against the acute convulsant dose of Pentylenetetrazole (PTZ, 90mg/kg, s.c.). eth-EN extract at 100mg/kg i.p concentration showed maximum protection against the PTZ induced mortality (P<0.05). eth-EN (100mg/kg) treated animals also showed significant reduction in the progression of epileptogenesis (P<0.05) when tested against the PTZ-induced (50mg/kg s.c.) chemical kindling model of epilepsy. The FT-IR spectra of this extract showed both known and unknown spectral peaks from which the presence of the functional groups; i.e. aromatics, diketones, alkenes, carbonyls, carboxylic acids and amide compounds were confirmed. The unknown peaks strongly suggested the presence of novel compounds that may be responsible for its anticonvulsant and antiepileptogenic activity. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi en_US
dc.subject Euphorbia nivulia Buch.-Ham en_US
dc.subject PTZ en_US
dc.subject epileps en_US
dc.subject seizure en_US
dc.subject FT-IR en_US
dc.title Evaluation of anticonvulsant and antiepileptogenic activity of Euphorbia nivulia in PTZ-induced kindling model of epilepsy in mice en_US
dc.type Article en_US


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