PASTIC Dspace Repository

REVIEW Therapeutic potential of carbonic anhydrase inhibitors

Show simple item record

dc.contributor.author Rahman, Shafiq-ur-
dc.contributor.author Bib, Sumbal
dc.contributor.author Javed, Tariq
dc.contributor.author Alam, Fiaz
dc.contributor.author Atif Ali, Zia ur Rehman
dc.contributor.author Quresh, Sayyad
dc.contributor.author Ali, Majeed
dc.contributor.author Ullah, Muhammad Hassham Hassan Bin
dc.contributor.author Asad, Syed Muhammad
dc.contributor.author Hasan, Farid
dc.contributor.author Sabatier, Jean-Marc
dc.contributor.author Rizvanov, Albert A
dc.date.accessioned 2022-12-15T04:42:30Z
dc.date.available 2022-12-15T04:42:30Z
dc.date.issued 2019-04-02
dc.identifier.citation Supuran, C. T., & Scozzafava, A. (2000). Carbonic anhydrase inhibitors and their therapeutic potential. Expert Opinion on Therapeutic Patents, 10(5), 575-600. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15111
dc.description.abstract Enzymes are biological catalyst involve in different biochemical reactions. But over activation of these biomolecules can cause disease thus different inhibitors and knockout therapies are use in current clinical practice. Carbonic anhydrases (CAs), a group of ubiquitously expressed metalloenzymes, are involved in numerous physiological and pathological processes, including gluconeogenesis, lipogenesis, ureagenesis, tumorigenicity and the growth and virulence of various pathogens. In addition to the established role of CA inhibitors (CAIs) as diuretics and antiglaucoma drugs, it has recently emerged that CAIs could have potential as novel anti-obesity, anticancer and anti-infective drugs. Furthermore, recent studies suggest that CA activation may provide a novel therapy for Alzheimer’s disease. This article discusses the biological rationale for the novel uses of inhibitors or activators of CA activity in multiple diseases, and highlights progress in the development of specific modulators of the relevant CA isoforms, some of which are now being evaluated in clinical trials en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi en_US
dc.subject Carbonic anhydrase en_US
dc.subject inhibitor en_US
dc.subject potential targets en_US
dc.subject therapeutic uses. en_US
dc.title REVIEW Therapeutic potential of carbonic anhydrase inhibitors en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account