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Metabolite profiling of Cycas revoluta leaf extract and docking studies on alpha-glucosidase inhibitory molecular targets by phytochemicals

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dc.contributor.author Arshad, Muhammad
dc.contributor.author Mumtaz, Muhammad Waseem
dc.contributor.author Chaudhary, Ayoub Rashid
dc.contributor.author Rashid, Umer
dc.contributor.author Ali, Mukhtar
dc.contributor.author Mukhtar, Hamid
dc.contributor.author Adnan, Ahmad
dc.contributor.author Ali Raza, Syed
dc.date.accessioned 2022-12-15T04:43:51Z
dc.date.available 2022-12-15T04:43:51Z
dc.date.issued 2019-03-20
dc.identifier.citation Arshad, M., Mumtaz, M. W., Chaudhary, A. R., Rashid, U., Ali, M., Mukhtar, H., ... & Raza, S. A. (2019). Metabolite profiling of Cycas revoluta leaf extract and docking studies on alpha-glucosidase inhibitory molecular targets by phytochemicals. Pak. J. Pharm. Sci, 32(2), 871-874. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15113
dc.description.abstract The leaves of Cycas revoluta were explored for their antioxidant, α-glucosidase and α-amylase inhibitory properties to develop safe and diet based therapeutic treatment of diabetes. In optimized fractionation, 60% ethanol provided the highest extract yield of 19.35±0.05a%, TPC 95.70±1.60a mg GAE/g and TFC 55 .60 ± 1.20a mg Rutin/g extract. The antioxidant and anti α-glucosidase activities of 60% ethanolic extracts were also promising and statistically significant as compared with remaining plant extracts. Ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-Q-TOF-MS/MS) analysis of the leaf extract revealed the presence of three apigenin derivatives, kaempferol derivative, hexadecenoic acid and citric acid. The binding energy values of molecular docking studies supported the synergistic behavior of leaf extract to inhibit α-glucosidase activity. The leaves of Cycas revoluta were proved to be apigenin rich natural pool of metabolites of antidiabetic importance to improvise food functionalities. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Antidiabetic en_US
dc.subject Cycas revoluta en_US
dc.subject optimized fractionation en_US
dc.subject phytochemical profiling. en_US
dc.title Metabolite profiling of Cycas revoluta leaf extract and docking studies on alpha-glucosidase inhibitory molecular targets by phytochemicals en_US
dc.type Article en_US


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