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In vitro Spectroscopic studies on drug interaction of cefpodoxime proxetil and H2 receptor blockers

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dc.contributor.author Iqbal, Sadia
dc.contributor.author Hassan, Sohail
dc.contributor.author Zaheer, Erum
dc.contributor.author Ahmed, Ateka
dc.contributor.author Hussain, Kanwal
dc.contributor.author Shereen
dc.contributor.author Furqan, Hina
dc.date.accessioned 2022-12-15T04:51:06Z
dc.date.available 2022-12-15T04:51:06Z
dc.date.issued 2019-03-20
dc.identifier.citation Iqbal, S., Hassan, S., Hassan, A., Ali, M., Nazim, U., Zaheer, E., ... & Furqan, H. (2019). In vitro Spectroscopic studies on drug interaction of cefpodoxime proxetil and H2 receptor blockers. Pak J Pharm Sci, 32(2Suppl), 881-887. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15119
dc.description.abstract One of the relatively advance 3rd generation cephalosporins, cefpodoxime proxetil, is being used all-around. Generally, these are used for the cure of infections allied to urinary and respiratory tract. These cephalosporins have showed a remarkable in vitro activity against many strains of bacteria which are resistant to other orally used active medicinal substances. It is the first oral 3rd generation cephalosporin to be used in the cure of skin infections. The practice of H2 receptor antagonists, concerning lots of treatments recommended in patients with different types of ulcers and allergic urticarial condition, is raising hazards of unwanted secondary outcomes and drug interactions. Learning of in-vitro interaction between cefpodoxime poxetil and H2 blockers (Ranitidine, Famotidine and Cimetidine) were examined applying UV/Visible spectrophotometry and Infrared spectrometry. In the existence of H2 receptor blockers, the cefpodoxime proxetil availability was found to be decreased in vitro only under specific conditions. Furthermore, complexes of Cefpodoxime proxetil-H2 receptor antagonists were manufactured approving the interaction of these drugs. Finally, the above mentioned spectrophotometric techniques were employed to examine the complexes formed (Cefpodoxime proxetil-cimetidine, cefpodoxime proxetil-famotidine and cefpodoxime proxetil-ranitidine). en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Drug interaction en_US
dc.subject cefpodoxime proxetil en_US
dc.subject IR-Spectroscopy en_US
dc.title In vitro Spectroscopic studies on drug interaction of cefpodoxime proxetil and H2 receptor blockers en_US
dc.type Article en_US


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