dc.contributor.author |
Shahzad, Muhammad Adeel |
|
dc.contributor.author |
Naqvi, Syed Ali Raza |
|
dc.contributor.author |
Rasheed, Rashid |
|
dc.contributor.author |
Yameen, Muhammad |
|
dc.contributor.author |
Anjum, Fozia |
|
dc.contributor.author |
Ahmed, Muhammad Tauqeer |
|
dc.contributor.author |
Hussain, Zaib |
|
dc.contributor.author |
Gillani, Syed Jawad Hussain |
|
dc.date.accessioned |
2022-12-15T05:13:46Z |
|
dc.date.available |
2022-12-15T05:13:46Z |
|
dc.date.issued |
2017-11-04 |
|
dc.identifier.citation |
Shahzad, M. A., Naqvi, S. A. R., Rasheed, R., Yameen, M., Anjum, F., Ahmed, M. T., ... & Gillani, S. J. H. (2017). Radiolabeling of benzylpenicillin with lutetium-177: Quality control and biodistribution study to develop theranostic infection imaging agent. Pakistan Journal of Pharmaceutical Sciences, 30. |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/15125 |
|
dc.description.abstract |
Benzylpenicillin acts through binding with beta-lactamase enzyme and inhibiting the bacterial cell wall
biosynthesis. Therefore, the radiolabeling of benzylpenicillin with lutetium-177 is expected to serve as a theranostic agent for deep-seated bacterial infections. The radiolabeling of benzylpenicillin resulted ~93% radiochemical yield at optimized reaction conditions. Radiochemical purity analysis was tested with the help of Whatman No. 2 paper and instant thin layer chromatography. Biodistribution study with healthy New Zeeland white rabbit revealed moderate accumulation in different organs. Kidneys are the major organs, showed not more than 4.57±0.89% injected dose per gram organ (ID/gm organ) at 1 h time point and 3.48±1.11% ID/gm organ at 6 h time point. The accumulation of tracer agent in liver was found in the range of 7.42±2.42% to 9.09±2.76 ID/gm organ. The glomerular filtration rate studies revealed rapid clearance – omitting the chance of nephrotoxicity. The radiolabeling yield, biodistribution and glomerular filtration rate results revealed 177Lu-benzylpencillin could be a potential candidate to diagnose the deep-seated bacterial infection. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
en_US |
dc.subject |
Benzylpenicillin |
en_US |
dc.subject |
Infection imaging |
en_US |
dc.subject |
radiopharmaceuticals |
en_US |
dc.subject |
nuclear medicine |
en_US |
dc.subject |
lutetium-177 |
en_US |
dc.title |
Radiolabeling of benzylpenicillin with lutetium-177: Quality control and biodistribution study to develop theranostic infection imaging agent |
en_US |
dc.type |
Article |
en_US |