PASTIC Dspace Repository

Radiolabeling of benzylpenicillin with lutetium-177: Quality control and biodistribution study to develop theranostic infection imaging agent

Show simple item record

dc.contributor.author Shahzad, Muhammad Adeel
dc.contributor.author Naqvi, Syed Ali Raza
dc.contributor.author Rasheed, Rashid
dc.contributor.author Yameen, Muhammad
dc.contributor.author Anjum, Fozia
dc.contributor.author Ahmed, Muhammad Tauqeer
dc.contributor.author Hussain, Zaib
dc.contributor.author Gillani, Syed Jawad Hussain
dc.date.accessioned 2022-12-15T05:13:46Z
dc.date.available 2022-12-15T05:13:46Z
dc.date.issued 2017-11-04
dc.identifier.citation Shahzad, M. A., Naqvi, S. A. R., Rasheed, R., Yameen, M., Anjum, F., Ahmed, M. T., ... & Gillani, S. J. H. (2017). Radiolabeling of benzylpenicillin with lutetium-177: Quality control and biodistribution study to develop theranostic infection imaging agent. Pakistan Journal of Pharmaceutical Sciences, 30. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15125
dc.description.abstract Benzylpenicillin acts through binding with beta-lactamase enzyme and inhibiting the bacterial cell wall biosynthesis. Therefore, the radiolabeling of benzylpenicillin with lutetium-177 is expected to serve as a theranostic agent for deep-seated bacterial infections. The radiolabeling of benzylpenicillin resulted ~93% radiochemical yield at optimized reaction conditions. Radiochemical purity analysis was tested with the help of Whatman No. 2 paper and instant thin layer chromatography. Biodistribution study with healthy New Zeeland white rabbit revealed moderate accumulation in different organs. Kidneys are the major organs, showed not more than 4.57±0.89% injected dose per gram organ (ID/gm organ) at 1 h time point and 3.48±1.11% ID/gm organ at 6 h time point. The accumulation of tracer agent in liver was found in the range of 7.42±2.42% to 9.09±2.76 ID/gm organ. The glomerular filtration rate studies revealed rapid clearance – omitting the chance of nephrotoxicity. The radiolabeling yield, biodistribution and glomerular filtration rate results revealed 177Lu-benzylpencillin could be a potential candidate to diagnose the deep-seated bacterial infection. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Benzylpenicillin en_US
dc.subject Infection imaging en_US
dc.subject radiopharmaceuticals en_US
dc.subject nuclear medicine en_US
dc.subject lutetium-177 en_US
dc.title Radiolabeling of benzylpenicillin with lutetium-177: Quality control and biodistribution study to develop theranostic infection imaging agent en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account