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The hepatoprotective effects of aquatic extract of Levisticum officinale against paraquat hepatocyte toxicity

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dc.contributor.author Afarnegan, Hasan
dc.contributor.author Shahraki, Ali
dc.contributor.author Shahraki, Jafar
dc.date.accessioned 2022-12-15T05:14:44Z
dc.date.available 2022-12-15T05:14:44Z
dc.date.issued 2017-11-06
dc.identifier.citation Afarnegan, H., Shahraki, A., & Shahraki, J. (2017). The hepatoprotective effects of aquatic extract of Levisticum officinale against paraquat hepatocyte toxicity. Pakistan journal of pharmaceutical sciences, 30. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15127
dc.description.abstract Paraquat is extensively used as a strong nitrogen-based herbicide for controlling weeds in agriculture. This herbicide is extremely toxic to humans and induces multiorgan failure due to accumulation in the cells. So far, many instances of fatal poisoning have been reported. Paraquat is metabolized primarily in the liver. Accordingly, the effects of aquatic Levisticum officinale extract on biochemical factors and oxidative status were evaluated in hepatocytes exposed to paraquat in this study. The results showed that paraquat-induced hepatocyte destruction is mediated by reactive oxygen species (ROS) production. The aquatic extracts of Levisticum officinale (100, 200, and 300µg/mL) could prevent lipid peroxidation and reduction in the potential of mitochondrial membranes (P<0.05). The antioxidants, ROS scavengers (mannitol, dimethyl sulfoxide, and α-tocopherol), and mitochondrial permeability transition pore-sealing agent (carnitine) inhibited the effects of paraquat. The pore-sealing compound inhibited hepatotoxicity, indicating that paraquat induces cell death via mitochondrial pathways. Hepatic cell death due to paraquat could be prevented by hepatocyte pretreatment with aquatic Levisticum officinale extracts, antioxidants, and ROS scavengers; therefore, oxidative stress might directly reduce the mitochondrial membrane potential. In conclusion, paraquat hepatotoxicity may be associated with oxidative stress and maintained by the disruption of mitochondrial membrane potential. Levisticum officinale aquatic extract, presumably due to its strong antioxidant properties, could protect against the destructive effects of paraquat on rat hepatocytes en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Paraquat en_US
dc.subject oxidative stress en_US
dc.subject Levisticum officinale en_US
dc.subject hepatocyte protection en_US
dc.title The hepatoprotective effects of aquatic extract of Levisticum officinale against paraquat hepatocyte toxicity en_US
dc.type Article en_US


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