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HPLC and GC-MS: Identification and Quantification of Strychnine and Brucine in Strychnos nux-vomica leaves

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dc.contributor.author Maddisetty, PN Prasad
dc.contributor.author Doss, VA
dc.contributor.author S, Mohanasundaram
dc.contributor.author V, Srinivasarao
dc.contributor.author T, Mohanbabu
dc.date.accessioned 2022-12-15T05:15:34Z
dc.date.available 2022-12-15T05:15:34Z
dc.date.issued 2017-11-07
dc.identifier.citation Maddisetty, P. P., Doss, V. A., Mohanasundaram, S., Srinivasarao, V., & Mohanbabu, T. (2017). HPLC and GC-MS: Identification and Quantification of Strychnine and Brucine in Strychnos nux-vomica leaves. Pakistan Journal of Pharmaceutical Sciences, 30(6 (Supplementary)), 2369-2373. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15128
dc.description.abstract In this study, we have aimed to analyze the phytochemical composition of this plant and the concentration of strychnine and brucine. The identification of bioactive compounds was done by GC-MS with NIST Library. Strychnine and Brucine were quantified using HPLC. Twenty one medicinal bio active compounds were identified from the Strychnos nux-vomica leaf ethanolic extract. Strychnine is showing 28.43% purity and brucine was not detected in GCMS analysis. Quantified the concentration of strychnine (0.6 mg in 500mg of extract) and brucine (1.6 mg in 500mg of extract) was done by HPLC against Strychnine and Brucine standard. These compounds are having natural properties of Anti-inflammatory, Hypocholesterole, Cancer preventive, Hepatoprotective, Antimicrobial, Antioxidant, Cardio protective, Antiaging, Antialzheimeran, Antidermatitic, Immunostimulant, Anthepatotoxic, biosynthesis of steroid hormones, Nematicide, Antiandrogenic, 5-alpha reductase inhibitor, antipsychotic, analgesic, apoptotic effect, antidepressant, antidote for snake poisoning and diabetic activity. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Strychnos nux-vomica en_US
dc.subject GCMS en_US
dc.subject HPLC en_US
dc.subject identification en_US
dc.subject quantification en_US
dc.title HPLC and GC-MS: Identification and Quantification of Strychnine and Brucine in Strychnos nux-vomica leaves en_US
dc.type Article en_US


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