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Vasorelaxant effect of essential oil isolated from Nigella sativa L. seeds in rat aorta: Proposed mechanism

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dc.contributor.author Cherkaoui-Tangi, Khadija
dc.contributor.author Israili, Zafar Hasan
dc.contributor.author Lyoussi, Badiaâ
dc.date.accessioned 2022-12-15T05:18:25Z
dc.date.available 2022-12-15T05:18:25Z
dc.date.issued 2016-01-20
dc.identifier.citation Cherkaoui-Tangi, K., Israili, Z. H., & Lyoussi, B. (2016). Vasorelaxant effect of essential oil isolated from Nigella sativa L. seeds in rat aorta: Proposed mechanism. Pakistan Journal of Pharmaceutical Sciences, 29(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15133
dc.description.abstract The effect of the essential oil extracted from Nigella sativa (L.) seeds (Nigella oil) was investigated for its vasorelaxant activity on isolated rat aorta. Nigella oil at concentrations of 10-100µg/mL elicited a dose-dependent relaxation of the aorta, which was pre-contracted with noradrenaline (NA, 10-6 M) or KCl (100mM). In the presence of Nigella oil (75µg/mL, the dose response curves to increasing concentrations of NA (10-9 M to 10-4M) or KCl (10mM100mM) were displaced downwards, indicating inhibition of the vasoconstrictive effect. This relaxation effect was independent of the presence of endothelium. In addition, the vasodilatory activity of the Nigella oil was not affected by pre-treatment of the rings with NG-nitro-L-Arginine (an inhibitor of endothelial nitric oxide synthase; 0.1mM), suggesting that the vasorelaxant effect is not mediated by nitric oxide. Furthermore, pre-treatment of the rings with Nigella oil (75µg/mL suppressed the tension increment produced by increasing external calcium concentration (0.25mM to 1.5mM). Tin conclusion, the essential oil extracted from Nigella sativa seeds produces smooth muscle relaxation, which is independent of endothelium and is not mediated by nitric oxide. The results also suggest that the vasorelaxing effect of the oil results from the blockade of both voltage-sensitive and receptor-operated calcium channels, and this may have therapeutic significance, in that Nigella oil may be useful as an antihypertensive agent in humans. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Essential Oil en_US
dc.subject Nigella sativa en_US
dc.subject endothelium en_US
dc.subject calcium channel en_US
dc.subject vasodilator, rat en_US
dc.title Vasorelaxant effect of essential oil isolated from Nigella sativa L. seeds in rat aorta: Proposed mechanism en_US
dc.type Article en_US


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