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The role of Glutathione, Cysteine and D-Penicillamine in exchanging Palladium and Vanadium metals from albumin metal complex

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dc.contributor.author Mukhtiar, Muhammad
dc.contributor.author Jan, Syed Umer
dc.contributor.author Ullah, Ihsan
dc.contributor.author Hussain, Abid
dc.contributor.author Ullah, Izhar
dc.contributor.author Gul, Rahman
dc.contributor.author Ali, Essa
dc.contributor.author Jabbar, Abdul
dc.contributor.author Kuthu, Zulfiqar Hussan
dc.contributor.author Wasim, Muhammad
dc.contributor.author Khan, Muhammad Farid
dc.date.accessioned 2022-12-15T05:24:15Z
dc.date.available 2022-12-15T05:24:15Z
dc.date.issued 2017-11-13
dc.identifier.citation Mukhtiar, M., Jan, S. U., Ullah, I., Hussain, A., Ullah, I., Gul, R., ... & Khan, M. F. (2017). The role of Glutathione, Cysteine and D-Penicillamine in exchanging Palladium and Vanadium metals from albumin metal complex. Pakistan Journal of Pharmaceutical Sciences, 30. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15136
dc.description.abstract Thiol groups are extensively present across biological systems being found in range of small molecules (e.g. Glutathione, Homo-cysteine) and proteins (e.g. albumin, haemo-globin). Albumin is considered to be a major thiol containing protein present in circulating Plasma. Albumin contains a single thiolate group located at cysteine-34(cys-34) at its active site. Albumin also binds a wide variety of metals and metals complexes at various sites around the protein. Usually heavy metals are preferentially attached with the thiol group of albumin. The binding of heavy metals at cys-34 provides a mechanism by which the residence time of potentially toxic species in the body can be increased. In this research we have assessed the oxidative modification of and metal binding capacity of cys-34 with heavy metals Palladium and Vanadium to investigate the ease with which it is possible to effect disulfide-thiol exchange at this sites/or remove a metal bound at this position. Both the metals were treated with albumin and then the albumin metals (Pd and V) complexes were treated with small thoil molecules like Glutathione, Cysteine and D-Penicillamine. Our finding showed that the albumin thiol group retained the metals with itself by forming some strong bonding with the Thiols group, it is concluded from this finding that if by chance both the metals enter the living system; strongly disturb the chemistry and physiological function of this bio-molecule. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Albumin en_US
dc.subject Glutathione en_US
dc.subject Cysteine en_US
dc.subject D-Penicillamine en_US
dc.subject Palladium (Pd) en_US
dc.subject Vanadium (V) en_US
dc.title The role of Glutathione, Cysteine and D-Penicillamine in exchanging Palladium and Vanadium metals from albumin metal complex en_US
dc.type Article en_US


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