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A Comparative biochemical study on two marine endophytes, Bacterium SRCnm and Bacillus sp. JS, Isolated from red sea algae

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dc.contributor.author Ahmed, Eman Fadl
dc.contributor.author Mokhtar Hassan, Hossam
dc.contributor.author Ezzat Rateb, Mostafa
dc.contributor.author Abdel-Wahab, Noha
dc.contributor.author Sameer, Somayah
dc.contributor.author Ebel, Rainer
dc.contributor.author Aly Taie, Hanan Anwar
dc.contributor.author Sayed Abdel Hameed, Muhammad
dc.contributor.author Hammouda, Ola
dc.date.accessioned 2022-12-15T06:05:38Z
dc.date.available 2022-12-15T06:05:38Z
dc.date.issued 2016-01-20
dc.identifier.citation Ahmed, E. F., Hassan, H. M., Rateb, M. E., Abdel-Wahab, N., Sameer, S., Ebel, R., ... & Hammouda, O. (2016). A Comparative biochemical study on two marine endophytes, Bacterium SRCnm and Bacillus sp. JS, Isolated from red sea algae. Pakistan journal of pharmaceutical sciences, 29(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15137
dc.description.abstract Two marine endophytic bacteria were isolated from the Red Sea algae; a red alga; Acanthophora dendroides and the brown alga Sargassum sabrepandum. The isolates were identified based on their 16SrRNA sequences as Bacterium SRCnm and Bacillus sp. JS. The objective of this study was to investigate the potential anti-microbial and antioxidant activities of the extracts of the isolated bacteria grown in different nutrient conditions. Compared to amoxicillin (25µg/disk) and erythromycin (15µg/disk), the extracts of Bacterium SRCnm in media II, III, IV and V were potent inhibitors of the gram-positive bacterium Sarcina maxima even at low concentrations. Also, the multidrug resistant Staphylococcus aureus (MRSA) was more sensitive to the metabolites produced in medium (II) of the same endophyte than erythromycin (15µg/disk). A moderate activity of the Bacillus sp. JS extracts of media I and II was obtained against the same pathogen. The total compounds (500ug/ml) of both isolated endophytes showed moderate antioxidant activities (48.9% and 46.1%, respectively). LC/MS analysis of the bacterial extracts was carried out to investigate the likely natural products produced. Cyclo(D-cis-Hyp-L-Leu), dihydrosphingosine and 2-Amino-1,3hexadecanediol were identified in the fermentation medium of Bacterium SRCnm, whereas cyclo (D-Pro-L-Tyr) and cyclo (L-Leu-L-Pro) were the suggested compounds of Bacillus sp. JS. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Endophytes en_US
dc.subject antimicrobial activity en_US
dc.subject antioxidant en_US
dc.subject LC/MS analysis en_US
dc.title A Comparative biochemical study on two marine endophytes, Bacterium SRCnm and Bacillus sp. JS, Isolated from red sea algae en_US
dc.type Article en_US


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