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Cytotoxic and acute toxicity studies of isoniazid derivatives

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dc.contributor.author Naeem, Sabahat
dc.contributor.author Akhtar, Shamim
dc.contributor.author Lei, Zi-Ning
dc.contributor.author Lu, Kimberly
dc.contributor.author Zafar, Shaista
dc.contributor.author Ahmed, Ahsaan
dc.contributor.author Ali, Mohsin
dc.contributor.author Ahmed, Mansoor
dc.contributor.author Chen, Zhe-Sheng
dc.date.accessioned 2022-12-15T06:06:31Z
dc.date.available 2022-12-15T06:06:31Z
dc.date.issued 2017-11-14
dc.identifier.citation Naeem, S., Akhtar, S., Lei, Z. N., Lu, K., Zafar, S., Ahmed, A., ... & Chen, Z. S. (2017). Cytotoxic and acute toxicity studies of isoniazid derivatives. Pak J Pharm Sci S, 30, 2411-5. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15138
dc.description.abstract Cancer is ultimately the result of cells that hysterically grow and do not die. Cells can experience uncontrolled growth if there are mutations to DNA, and therefore, alterations to the genes involved in cell division. Cancer occurs when a cell's gene mutations make the cell unable to correct DNA damage and is unable to destroy itself. There are over 100 different types of cancer each classified by the type of initially affected cell. Isoniazid, a well-known antitubercular agent has been reported to exhibit some cytotoxic activity. This finding prompt us to carry out this study where isoniazid and its sixteen derivatives were studied for any possible cytotoxic activity against Human astrocytoma SNB-19 cells, human Dukes' type C colorectal adenocarcinoma HCT-15 cells, human Dukes' type D colorectal adenocarcinoma COLO-205 cells, and human prostate adenocarcinoma (grade IV) PC-3 cells. Among the test compounds, SN-07 (a phenacyl derivative with para phenyl substitution) demonstrated slight cytotoxic effects on two types of human colorectal adenocarcinoma cells HCT-15 and COLO-205. Moreover, the acute toxicity of the compounds was also estimated in which some compounds were evaluated with more LD50 values than isoniazid. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Isoniazid en_US
dc.subject Cytotoxicity en_US
dc.subject Acute toxicity en_US
dc.subject LD50 en_US
dc.title Cytotoxic and acute toxicity studies of isoniazid derivatives en_US
dc.type Article en_US


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