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Synthesis and antibacterial screening of S-substituted derivatives of 5-(3,4-methylenedioxyphenyl)-1,3,4-oxadiazol-2-thiol

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dc.contributor.author Siddiqa, Asia
dc.contributor.author Rehman, Aziz-ur
dc.contributor.author Abbasi, Muhammad Athar
dc.contributor.author Siddiqui, Sabahat Zahra
dc.contributor.author Rasool, Shahid
dc.contributor.author Sattar, Almas
dc.contributor.author Muhammed Khan, Khalid
dc.contributor.author Ahmad, Irshad
dc.contributor.author Afzal, Saira
dc.date.accessioned 2022-12-15T06:08:09Z
dc.date.available 2022-12-15T06:08:09Z
dc.date.issued 2016-01-20
dc.identifier.citation Siddiqa, A., Abbasi, M. A., Siddiqui, S. Z., Rasool, S., Sattar, A., Khan, K. M., ... & Afzal, S. (2016). Synthesis and antibacterial screening of S-substituted derivatives of 5-(3, 4-methylenedioxyphenyl)-1, 3, 4-oxadiazol-2-thiol. Pakistan Journal of Pharmaceutical Sciences, 29(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15140
dc.description.abstract The most emerging class among the heterocyclic compounds is 1,3,4-oxadiazoles for their diverse biological activities. In the present research work, piperonylic acid (1) was converted consecutively into corresponding ester (2), hydrazide (3) and 1,3,4-oxadiazole (4) through intermolecular cyclization. The synthesized compound 4 was subjected further to S-alkylation/aralkylation, using alkyl/aralkyl halides (5a-m) and S-substituted-1,3,4-oxadiazole derivatives were synthesized (6a-m). The structure elucidation of the synthesized molecules was processed through 1H-NMR, IR and mass spectral data. The antibacterial activity showed these molecules moderately good inhibitors of gram-negative and gram-positive bacteria. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject 1,3,4-oxadiazole en_US
dc.subject antibacterial activity en_US
dc.subject piperonylic acid. en_US
dc.title Synthesis and antibacterial screening of S-substituted derivatives of 5-(3,4-methylenedioxyphenyl)-1,3,4-oxadiazol-2-thiol en_US
dc.type Article en_US


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