dc.contributor.author |
Siddiqa, Asia |
|
dc.contributor.author |
Rehman, Aziz-ur |
|
dc.contributor.author |
Abbasi, Muhammad Athar |
|
dc.contributor.author |
Siddiqui, Sabahat Zahra |
|
dc.contributor.author |
Rasool, Shahid |
|
dc.contributor.author |
Sattar, Almas |
|
dc.contributor.author |
Muhammed Khan, Khalid |
|
dc.contributor.author |
Ahmad, Irshad |
|
dc.contributor.author |
Afzal, Saira |
|
dc.date.accessioned |
2022-12-15T06:08:09Z |
|
dc.date.available |
2022-12-15T06:08:09Z |
|
dc.date.issued |
2016-01-20 |
|
dc.identifier.citation |
Siddiqa, A., Abbasi, M. A., Siddiqui, S. Z., Rasool, S., Sattar, A., Khan, K. M., ... & Afzal, S. (2016). Synthesis and antibacterial screening of S-substituted derivatives of 5-(3, 4-methylenedioxyphenyl)-1, 3, 4-oxadiazol-2-thiol. Pakistan Journal of Pharmaceutical Sciences, 29(1). |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/15140 |
|
dc.description.abstract |
The most emerging class among the heterocyclic compounds is 1,3,4-oxadiazoles for their diverse biological activities. In the present research work, piperonylic acid (1) was converted consecutively into corresponding ester (2), hydrazide (3) and 1,3,4-oxadiazole (4) through intermolecular cyclization. The synthesized compound 4 was subjected further to S-alkylation/aralkylation, using alkyl/aralkyl halides (5a-m) and S-substituted-1,3,4-oxadiazole derivatives were synthesized (6a-m). The structure elucidation of the synthesized molecules was processed through 1H-NMR, IR and mass spectral data. The antibacterial activity showed these molecules moderately good inhibitors of gram-negative and gram-positive bacteria. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
en_US |
dc.subject |
1,3,4-oxadiazole |
en_US |
dc.subject |
antibacterial activity |
en_US |
dc.subject |
piperonylic acid. |
en_US |
dc.title |
Synthesis and antibacterial screening of S-substituted derivatives of 5-(3,4-methylenedioxyphenyl)-1,3,4-oxadiazol-2-thiol |
en_US |
dc.type |
Article |
en_US |