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Anti-ulcer activity of the aqueous extract of Melastoma malabathricum L. leaf in rats

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dc.contributor.author Wan Zainulddin, Wan Noraziemah
dc.contributor.author Zabidi, Zalina
dc.contributor.author Kamisan, Farah Hidayah
dc.contributor.author Yahya, Farhana
dc.contributor.author Ismail, Noor Aisyah
dc.contributor.author Shamsahal Din, Nor Shafawati
dc.contributor.author Mamat, Siti Syariah
dc.contributor.author Hassan, Hadijah
dc.contributor.author Mohtarrudin, Norhafizah
dc.contributor.author Amiruddin Zakaria, d Zainul
dc.date.accessioned 2022-12-15T06:10:48Z
dc.date.available 2022-12-15T06:10:48Z
dc.date.issued 2016-01-20
dc.identifier.citation Zainulddin, W. N. W., Zabidi, Z., Kamisan, F. H., Yahya, F., Ismail, N. A., Din, N. S. S., ... & Zakaria, Z. A. (2016). Anti-ulcer activity of the aqueous extract of Melastoma malabathricum L. leaf in rats. Pakistan journal of pharmaceutical sciences, 29(1), 35-38. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15144
dc.description.abstract Melastoma malabathricum L. Smith (Melastomaceae) has been used in the Malay traditional culture to treat ulcer-based ailments. The objective of the present study was to investigate the potential anti-ulcer effect of aqueous extract of M. malabathricum leaves (AEMM) using ethanol- and indomethacin-induced gastric ulcer models in rats. Rats were divided into ten groups (n=6) and received DMSO (10%; negative group), ranitidine (100mg/kg; positive group) or AEMM (50, 250 and 500mg/kg) orally for 7 days and on the 8th day subjected to the respective gastric ulcer models. The stomachs were collected and subjected to macroscopic and microscopic analysis. At all groups tested, the AEMM exerted significant (p<0.05) anti-ulcer effect only against the ethanol-induced gastric ulcer model. The percentage of anti-ulcer for the 50-500mg/kg AEMM ranging between 50-82%, respectively. The macroscopic observations were supported by histological findings. In conclusion, AEMM exhibits potential anti-ulcer activity attributed to its previously proven high flavonoids content and antioxidant activity. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Melastoma malabathricum en_US
dc.subject Melastomaceae en_US
dc.subject anti-ulcer activity en_US
dc.subject aqueous extract en_US
dc.title Anti-ulcer activity of the aqueous extract of Melastoma malabathricum L. leaf in rats en_US
dc.type Article en_US


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