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The acetylcholinesterase (AChE) inhibition analysis of medaka (Oryzias latipes) in the exposure of three insecticides

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dc.contributor.author Zhu, Jianping
dc.contributor.author Huan, Cheng
dc.contributor.author Si, Guiyun
dc.contributor.author Yang, Haitang
dc.contributor.author Yin, Li
dc.contributor.author Ren, Qing
dc.contributor.author Ren, Baixiang
dc.contributor.author Fu, Rongshu
dc.contributor.author Miao, Mingsheng
dc.contributor.author Ren, Zongming
dc.date.accessioned 2022-12-15T06:12:48Z
dc.date.available 2022-12-15T06:12:48Z
dc.date.issued 2015-03-02
dc.identifier.citation Zhu, J., Huan, C., Si, G., Yang, H., Yin, L., Ren, Q., ... & Ren, Z. (2015). The acetylcholinesterase (AChE) inhibition analysis of medaka (Oryzias latipes) in the exposure of three insecticides. Pakistan Journal of Pharmaceutical Sciences, 28. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15147
dc.description.abstract The continuous effects on Acetylcholinesterase (AChE) activity of medaka (Oryzias latipes) caused by dichlorvos, methomyl and deltamethrin in vivo were investigated, and the trends of AChE activity inhibition due to the influence of these insecticides were discussed. The LC50-24h of dichlorvos, methomyl and deltamethrin on medaka were 2.3 mg/L, 0.2 mg/L, and 2.9×10-3 mg/L respectively. The result suggested that at the beginning of the exposure, the AChE activity might increase, and the AChE activity in dead individuals was obviously lower than the live individuals. Though the de novo synthesis of AChE in medaka might help the AChE activity recover, the trends during the exposure in different treatments were downward, and it showed both exposure time and concentration dependent. Meanwhile, higher temperature might cause the AChE inhibition earlier due to the higher metabolic rate. Therefore, as a specific biomarker for organophosphate, carbamate pesticides and pyrethroids, the degree of the AChE inhibition with in vivo conditions is a good tool in continuous monitoring of insecticides, which may induce the nerve conduction disorders. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Acetylcholinesterase (AChE) en_US
dc.subject medaka en_US
dc.subject in vivo en_US
dc.subject AChE inhibition en_US
dc.title The acetylcholinesterase (AChE) inhibition analysis of medaka (Oryzias latipes) in the exposure of three insecticides en_US
dc.type Article en_US


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