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Role of the antidiabetic drugs: Glibenclamide and metformin on the contractility of isolated rat uteri

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dc.contributor.author Elsayed Kelany, Mohamed
dc.contributor.author Alqahtani, Saeed
dc.contributor.author Alkuriji, Afrah
dc.contributor.author Yousef Al Omar, Suliman
dc.date.accessioned 2022-12-15T06:14:15Z
dc.date.available 2022-12-15T06:14:15Z
dc.date.issued 2016-01-20
dc.identifier.citation Kelany, M. E., Alqahtani, S., Alkuriji, A., & Al Omar, S. Y. (2016). Role of the antidiabetic drugs: Glibenclamide and metformin on the contractility of isolated rat uteri. Pakistan Journal of Pharmaceutical Sciences, 29(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15149
dc.description.abstract The current investigation has designed to study the role of two antidiabetics, glibenclamide and metformin on the spontaneous uterine contractions in the non-diabetic non-pregnant female rats. The rat uteri were isolated and allocated to two groups: 1) the glibenclamide group: After recording the normal spontaneous uterine contractions, the vehicle (ethanol) and glibenclamide molar concentrations (10-7, 10-6 and 10-5 M) were analyzed on uterine contractions by recording on smoked paper on a rotating kymograph drum, and 2) the metformin group: After recording the normal spontaneous uterine contractions, the metformin concentrations (10-7, 10-6 and 10-5 M) were analyzed on uterine contractions. Responses to the two drugs and vehicle control (ethanol) were recorded for 30 min. Glibenclamide has not significantly effected on the amplitude and frequency of spontaneous contractions of the isolated rat uteri. Metformin also has no significant effect on the amplitude and frequency of spontaneous contractions of the isolated rat uteri. In conclusion, the two oral antidiabetics glibenclamide and metformin have not changed both the amplitude and frequency of spontaneous uterine contractions in the non-pregnant non-diabetic female rats. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Glibenclamide en_US
dc.subject metformin en_US
dc.subject isolated uterus en_US
dc.subject myometrium en_US
dc.subject spontaneous contractions en_US
dc.subject non-pregnant nondiabetic female rats en_US
dc.title Role of the antidiabetic drugs: Glibenclamide and metformin on the contractility of isolated rat uteri en_US
dc.type Article en_US


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