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Clinical study of ganglioside (GM) combined with methylprednisolone (MP) for early acute spinal injury

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dc.contributor.author Xu, Dayong
dc.contributor.author Yang, Libin
dc.contributor.author Li, Yunpeng
dc.contributor.author Sun, Yongqiang
dc.date.accessioned 2022-12-15T06:18:08Z
dc.date.available 2022-12-15T06:18:08Z
dc.date.issued 2015-03-08
dc.identifier.citation Xu, D., Yang, L., Li, Y., & Sun, Y. (2015). Clinical study of ganglioside (GM) combined with methylprednisolone (MP) for early acute spinal injury. Pakistan journal of pharmaceutical sciences, 28. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15156
dc.description.abstract This paper aims to make an analysis of the effects of ganglioside (GM) combined with methylprednisolone (MP) in early acute spinal injury. Fifty-three patients with acute spinal cord injury were included in this study and they were randomly divided into experimental and control group. Twenty-seven patients in the control group were treated with MP, while the rest 26 patients received more GM based on that. By observing and comparing the clinical responses from patients and recovery time of all indexes, results came out: the curative rates in the experimental and control group were 50.0%, 40.7% respectively, and the total effective rates were 92.3%, 85.2% respectively. There was a remarkable difference between the two groups (P<0.05). Patients in the experimental group took 6.2±1.9d to restore their sphincter function, 11.2±2.8d to recover their muscle forces to over grade II, and 13.8±3.9d to return general activity, while the patients in the other group clearly spent longer time on recovery, that were 12.1±3.2, 19.2±4.6 and 23.9±5.6 respectively. The distinct difference between the two groups was of statistical significance (P<0.05). We conclude that GM has better curative effects than MP, for it is able to promote the recovery of nerve function for patients and greatly improve the prognosis. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Acute spinal cord injury en_US
dc.subject MP en_US
dc.subject GM en_US
dc.title Clinical study of ganglioside (GM) combined with methylprednisolone (MP) for early acute spinal injury en_US
dc.type Article en_US


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