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Expression of Cripto-1 gene protein and Activin-A in human lung adenocarcinoma tissue

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dc.contributor.author Shan, Yangyang
dc.contributor.author Li, Shenglei
dc.date.accessioned 2022-12-15T06:23:20Z
dc.date.available 2022-12-15T06:23:20Z
dc.date.issued 2015-03-14
dc.identifier.citation Shan, Y., & Li, S. (2015). Expression of Cripto-1 gene protein and Activin-A in human lung adenocarcinoma tissue. Pakistan journal of pharmaceutical sciences, 28. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15164
dc.description.abstract To research the expression in human lung adenocarcinoma tissue of Cripto-1 (teratocarcinoma derived growth factor-1) gene protein and Activin-A gene protein, and explore the relationship and clinical significance between the two gene protein and clinical pathological characteristic of lung adenocarcinoma. This study had applied the immunohistochemical method to detect the 188 cases of lung adenocarcinoma and expression of Cripto-1 protein and Activin-A protein in 100 cases of normal lung tissue. Then, analysis the relationship between these two-gene protein and clinical lung adenocarcinoma histopathological features, and inherent correlation between these two genes. The positive expression rate of Cripto-1 protein in lung adenocarcinoma tissue was significantly higher in normal lung tissue, while, the positive expression rate of Activin-A protein in lung adenocarcinoma tissue was significantly lower than in normal lung tissue. The high expression of Cripto-1 and low expression of Activin-A was closely related (each P<0.05) to the TNM staging of lung adenocarcinoma, lymph node metastasis and the main pathological tissue staging of lung adenocarcinoma. And the correlation analysis showed that it was negative correlation for the expression of Activin-A protein and Cripto-1 protein in lung adenocarcinoma. The over expression of Cripto-1 and the expression lack of Activin-A were correlated with the occurrence, development, metastasis and malignant degree of lung adenocarcinoma. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Lung adenocarcinoma en_US
dc.subject Cripto-1 en_US
dc.subject Activin-A en_US
dc.title Expression of Cripto-1 gene protein and Activin-A in human lung adenocarcinoma tissue en_US
dc.type Article en_US


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