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Enhancement of sodium taurocholate to the absorption of cefquinome

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dc.contributor.author Yu, Qinghua
dc.contributor.author Cao, Yufei
dc.contributor.author feng Liu, Li
dc.contributor.author xiang Jiang, Shan
dc.contributor.author Yang, Qian
dc.date.accessioned 2022-12-15T06:49:10Z
dc.date.available 2022-12-15T06:49:10Z
dc.date.issued 2016-01-20
dc.identifier.citation Yu, Q., Cao, Y., Liu, L. F., Jiang, S. X., & Yang, Q. (2016). Enhancement of sodium taurocholate to the absorption of cefquinome. Pakistan Journal of Pharmaceutical Sciences, 29(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15182
dc.description.abstract The objective of the research was to detect the enhancement effect of sodium taurocholate on the absorption of cefquinome both in Caco-2 cells and rats. The absorption efficiency of cefquinome was determined by high performance liquid chromatography and calculated with apparent permeability coefficients (Papp) after Caco-2 cell monolayers treated odium taurocholate (2 mmol/L) and cefquinome. The results showed that the absorption of cefquinome in Caco-2 cell monolayers was significantly increased with the sodium taurocholate (2mmol/L). Similar results were also detected in the rats orally administrated with 1 mL PBS of cefquinome (20mg/mL) containing different concentration of sodium taurocholate (5 mmol/L, 10mmol/L and 20mmol/L) respectively. Compared with control group, sodium taurocholate at 10 and 20 mmol/L increased the absorption of cefquinome in rats from 0.26±0.04µg/mL to 0.57±0.03µg/mL, 0.78 ±0.07µg/mL respectively. These results indicated that sodium taurocholate could increase the intestinal permeability in a concentration-dependent mode, which will be useful for clinical treatment. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Caco-2 cells en_US
dc.subject cefquinome en_US
dc.subject sodium taurocholate en_US
dc.subject absorption en_US
dc.title Enhancement of sodium taurocholate to the absorption of cefquinome en_US
dc.type Article en_US


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