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Counter effects of N. Sativa L. and P. ovata L. on indicative markers of non alcoholic fatty liver disease

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dc.contributor.author Syed Abbas, Afshan
dc.contributor.author Sheikh, Nadeem
dc.date.accessioned 2022-12-15T07:01:45Z
dc.date.available 2022-12-15T07:01:45Z
dc.date.issued 2016-01-20
dc.identifier.citation Abbas, A. S., & Sheikh, N. (2016). Counter effects of N. Sativa L. and P. ovata L. on indicative markers of non alcoholic fatty liver disease. Pakistan journal of pharmaceutical sciences, 29(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15189
dc.description.abstract The broad spectrum of non-alcoholic fatty liver disease (NAFLD) diseases ranges from simple liver inflammation to steatosis, leading to fibrosis and cirrhosis. Four groups of weaning (30g) Rattus norvegicus were designated as W-0, W-I, W-II and W-III. For sixteen weeks group W-0 was given standard pallet diet, group I consumed diet “A” (20% fat Sucrose + 33% tea whitener + 34% ground pallet diet +13% water), group W-II was fed on diet “B” (50g Nigella sativa seeds/kg of A) and group W-III was provided with diet “C” (50g Plantago ovata husks /Kg of A). The analysis of CBC, LFTs, and Lipid profile revealed that there were highly significant changes (P<0.001) in the MCV, PLT, Hb, MCH, MCHC, RBC, RDW%, WBC, MPV, Triglycerides, cholesterol, LDL and the significant alterations (P<0.01) in albumin, AST, bilirubin, AST/ALT, HDL and cholesterol/HDL were observed in the experimental groups when compared with control by using one way ANOVA. We concluded that high-energy diet can alter the blood profile. Moreover fat plummeting agents have counter impact on the hematology as well as serology of diet induced NAFLD in R. norvegicus. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Thrombocytopenia en_US
dc.subject NAFLD en_US
dc.subject hypertriglyceridemia en_US
dc.subject hypercholesterolemia en_US
dc.subject R. norvegicus en_US
dc.subject hyperbilirubinaemia en_US
dc.title Counter effects of N. Sativa L. and P. ovata L. on indicative markers of non alcoholic fatty liver disease en_US
dc.type Article en_US


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