dc.contributor.author |
Chen, Shao-Jun |
|
dc.contributor.author |
Wei-Cai, Wei-Cai |
|
dc.contributor.author |
Li, Zhao-Hui |
|
dc.date.accessioned |
2022-12-15T10:18:17Z |
|
dc.date.available |
2022-12-15T10:18:17Z |
|
dc.date.issued |
2018-03-19 |
|
dc.identifier.citation |
Chen, S. J., & Li, Z. H. (2018). Drug-target network of taxanes revealed by data mining. Pakistan Journal of Pharmaceutical Sciences, 31(2). |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/15210 |
|
dc.description.abstract |
Taxanes, mainly group paclitaxel and docetaxel, are amongst the most promising anticancer agents that are
widely used for a variety of tumor types. It is a great challenge to gain a quick overview of the molecular mechanisms of taxanes, owning to the massive amounts of data have been produced. Network pharmacology will be a powerful tool to uncover the drug-targets network of taxanes. In this study, drug-targets network of paclitaxel and docetaxel were constructed via STITCH by database mining, and its topological parameters and important nodes were analyzed. All will provide a systematic understanding for molecular mechanisms of pacltaxel and docetaxel in a quick and visual way. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
en_US |
dc.subject |
Data mining |
en_US |
dc.subject |
Docetaxel |
en_US |
dc.subject |
Network pharmacology |
en_US |
dc.subject |
Paclitaxel |
en_US |
dc.subject |
Taxanes |
en_US |
dc.title |
Drug-target network of taxanes revealed by data mining |
en_US |
dc.type |
Article |
en_US |