PASTIC Dspace Repository

Ethanolic extract of Nigella sativa protects Fe(II) induced lipid peroxidation in rat’s brain, kidney and liver homogenates

Show simple item record

dc.contributor.author Hassan, Waseem
dc.contributor.author Noreen, Hamsa
dc.contributor.author Ullah Khalil, Shafqat
dc.contributor.author Hussain, Arshad
dc.contributor.author Rehman, Shakilla
dc.contributor.author Sajjad, Shagufta
dc.contributor.author Rahman, Ata Ur
dc.contributor.author BT da Rocha, Joao
dc.date.accessioned 2022-12-15T10:19:18Z
dc.date.available 2022-12-15T10:19:18Z
dc.date.issued 2016-01-20
dc.identifier.citation Hassan, W., Noreen, H., Khalil, S. U., Hussain, A., Rehman, S., Sajjad, S., ... & da Rocha, J. B. (2016). Ethanolic extract of Nigella sativa protects Fe (II) induced lipid peroxidation in rat's brain, kidney and liver homogenates. Pakistan Journal of Pharmaceutical Sciences, 29(1). en_US
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15212
dc.description.abstract The study describes the effect of ethanolic extract of Nigella sativa against Fe(II) induced lipid peroxidation. Basal and Fe(II) induced thiobarbituric acid reactive species (TBARS) production was significantly inhibited by the ethanolic extract of Nigella sativa at 25-200µg/ml. Our data revealed that the extract has high DPPH radical scavenging activity at highest tested concentrations. The extract significantly chelated Fe(II) and scavenged hydroxyl (OH●) radical at 25-200µg/ml concentration. The nutritional analysis was performed and carbohydrate, fats, fiber, protein, moisture and ash content were measured in the studied extract. The phytochemical analysis confirmed the presence of alkaloid, carbohydrate & sugar, glycosides, phenolic compounds, flavonoids, protein and amino acid, phytosterols, tannins, gum and mucilage. The extract also showed significant antimicrobial activities against 10 bacterial strains i.e. Salmonella typhi, Bacillus subtilis, Bacillus cereus, Klebsiella pneumonia, Escheria coli, Xanthomonas, Salmonella heidelberg, Staphylococcus aureus, Clostridium and Escheria coli (human) and 5 fungal strains i.e. Aspergillus niger, Entomola, Aspergillus flavus, Alternaria alternata and Penicillium. This study confirms the potential antioxidant and antimicrobial activities of ethanolic extract of Nigella sativa which can be considered not only as a diet supplement but can be used against a variety of free radical induced damage diseases en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Nigella sativa en_US
dc.subject lipid peroxidation en_US
dc.subject antimicrobial activities en_US
dc.title Ethanolic extract of Nigella sativa protects Fe(II) induced lipid peroxidation in rat’s brain, kidney and liver homogenates en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account