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Sensitivity pattern of ceftriaxone against different clinical isolates

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dc.contributor.author Bushra, Rabia
dc.contributor.author Sial, Ali Akbar
dc.contributor.author Rizvi, Mehwish
dc.contributor.author Shafiq, Yousra
dc.contributor.author Aslam, Nousheen
dc.contributor.author Bano, Nusrat
dc.date.accessioned 2022-12-15T10:21:32Z
dc.date.available 2022-12-15T10:21:32Z
dc.date.issued 2016-01-20
dc.identifier.citation Bushra, R., Sial, A. A., Rizvi, M., Shafiq, Y., Aslam, N., & Bano, N. (2016). Sensitivity pattern of ceftriaxone against different clinical isolates. Pakistan Journal of Pharmaceutical Sciences, 29(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15217
dc.description.abstract Emerging resistance against broad-spectrum antibiotics for standard empiric therapy is a global concern. Ceftriaxone (broad spectrum, third generation cephalosporin) is widely used in tertiary care settings to treat severe bacterial infections usually non-responsive to other antibiotics. The aim of the study is to evaluate the current sensitivity pattern of ceftriaxone (30µg/disk) among different clinical isolates. For this purpose, three hundred clinical isolates including Escherichia coli (25%), Staphylococcus aureus (30%), Salmonella typhi (17%) and Klebsiella pneumoniae (20%) were collected from different pathological laboratories of Karachi, Pakistan. The in-vitro sensitivity of different Gram positive and Gram-negative bacteria was determined by disk-diffusion technique using 0.5 McFarland standard. Results showed that ceftriaxone was highly sensitive against Escherichia coli (90%) and least sensitive against Klebsiella pneumoniae (65%). It is concluded that the sensitivity of ceftriaxone is progressively decreasing in comparison with past studies creating an alarming situation. Therefore, continuous surveillance is required to determine the current resistance status of clinical pathogens and for effective anti-microbial therapy. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Ceftriaxone en_US
dc.subject resistance en_US
dc.subject antibiotic en_US
dc.subject clinical isolates en_US
dc.subject pathogens en_US
dc.title Sensitivity pattern of ceftriaxone against different clinical isolates en_US
dc.type Article en_US


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