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Antifungal and cytotoxic activities of selected medicinal plants from Malaysia

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dc.contributor.author Chan, Yik Sin
dc.contributor.author Cheah, Yit Hong
dc.contributor.author Chong, Poh Zen
dc.contributor.author Lai Khor, Hui
dc.contributor.author Siang Teh, Wen
dc.contributor.author Khoo, Kong Soo
dc.contributor.author Chooi Ong, Hean
dc.contributor.author Weng Sit, Nam
dc.date.accessioned 2022-12-15T10:32:24Z
dc.date.available 2022-12-15T10:32:24Z
dc.date.issued 2018-01-20
dc.identifier.citation Chan, Y. S., Cheah, Y. H., Chong, P. Z., Khor, H. L., Teh, W. S., Khoo, K. S., ... & Sit, N. W. (2018). Antifungal and cytotoxic activities of selected medicinal plants from Malaysia. Pakistan journal of pharmaceutical sciences, 31(1), 119-127. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15226
dc.description.abstract This study was conducted to investigate the antifungal potential and cytotoxicity of selected medicinal plants from Malaysia. The extracts from the stem of Cissus quadrangularis and the leaves of Asplenium nidus, Pereskia bleo, Persicaria odorata and Sauropus androgynus were assayed against six fungi using p-iodonitrotetrazolium-based on colorimetric broth microdilution method. All the plant extracts were found to be fungicidal against at least one type of fungus. The strongest fungicidal activity (minimum fungicidal concentration=0.16 mg/mL) were exhibited by the hexane extract of C. quadrangularis, the hexane, chloroform, ethanol and methanol extracts of P. bleo, the hexane and ethyl acetate extracts of P. odorata, and the water extract of A. nidus. In terms of cytotoxicity on the African monkey kidney epithelial (Vero) cells, the chloroform extract of P. odorata produced the lowest 50% cytotoxic concentration (100.3 ± 4.2 µg/mL). In contrast, none of the water extracts from the studied plants caused significant toxicity on the cells. The water extract of A. nidus warrants further investigation since it showed the strongest fungicidal activity and the highest total activity (179.22 L/g) against Issatchenkia orientalis, and did not cause any toxicity to the Vero cells. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Cytotoxicity en_US
dc.subject extraction, fungistatic en_US
dc.subject fungicidal, Vero cell en_US
dc.subject medicinal plants en_US
dc.title Antifungal and cytotoxic activities of selected medicinal plants from Malaysia en_US
dc.type Article en_US


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