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Pharmacological validation of the folkloric uses of Cyperus rotundus L. in different ailments: An in vivo and in vitro research

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dc.contributor.author Hussain, Musaddique
dc.contributor.author Waqas, Hafiz Muhammad
dc.contributor.author Hussain, Ikhlaq
dc.contributor.author Majeed, Abdul
dc.contributor.author Raza, Shahid Masood
dc.contributor.author Janbaz, Khalid Hussain
dc.date.accessioned 2022-12-15T10:36:45Z
dc.date.available 2022-12-15T10:36:45Z
dc.date.issued 2018-01-20
dc.identifier.citation Hussain, M., Waqas, H. M., Hussain, I., Majeed, A., Raza, S. M., & Janbaz, K. H. (2018). Pharmacological validation of the folkloric uses of Cyperus rotundus L. in different ailments: An in vivo and in vitro research. Pakistan Journal of Pharmaceutical Sciences, 31(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15234
dc.description.abstract In vivo and in vitro research study was conducted on Cyperus rotundus to evaluate the sound mechanistic background in the treatment of gastrointestinal, bronchial and vascular disorders as well as in pain, emesis, pyrexia and bacterial infections. Results showed that crude extract of Cyperus rotundus (Cr.Cr) exhibited the dose-dependent spasmolytic effect in rabbit jejunum by inhibiting the spontaneous and K+ (80 mM)-induced contractions. Pretreatment of tissue with Cr. Cr caused the rightward shift of calcium concentration response curves, similar to verapamil. Cr. Cr also caused the relaxation of K+(80 mM)- and carbachol (1 µM)-induced contractions of trachea preparations, similar to that of verapamil. Moreover, Cr. Cr also relaxed the contraction induced by the K+ (80 mM) and phenylephrine (1 µM) of aorta preparations. Data show that C. rotundus possess the spasmolytic, bronchodilator and vasodilator activities possibly through calcium channels blockade; validating its folkloric use in diarrhea, dyspepsia, bronchitis, asthma and hypertension in addition to antibacterial, antiemetic, antipyretic and analgesic activities. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Spasmolytic en_US
dc.subject bronchodilation en_US
dc.subject vasodilatation, Ca+2 en_US
dc.subject antagonist, antiemetic en_US
dc.title Pharmacological validation of the folkloric uses of Cyperus rotundus L. in different ailments: An in vivo and in vitro research en_US
dc.type Article en_US


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