PASTIC Dspace Repository

Neurite outgrowth properties of Calotropis procera: In search for a neuroprotectant

Show simple item record

dc.contributor.author Aisha Kamal, Aisha Kamal
dc.contributor.author Zafar Saeed Saify, Zafar Saeed Saify
dc.contributor.author Khawar Saeed Jamali, Khawar Saeed Jamali
dc.contributor.author Priya Tufail, Priya Tufail
dc.contributor.author Aiman Kanwal, Aiman Kanwal
dc.contributor.author Khan, Faisal
dc.contributor.author Sonia Siddiqui, Sonia Siddiqui
dc.date.accessioned 2022-12-15T10:39:47Z
dc.date.available 2022-12-15T10:39:47Z
dc.date.issued 2018-01-03
dc.identifier.citation Kamal, A., Saify, Z. S., Jamali, K. S., Tufail, P., Kanwal, A., Khan, F., & Siddiqui, S. (2018). Neurite outgrowth properties of Calotropis procera: In search for a neuroprotectant. Pakistan Journal of Pharmaceutical Sciences, 31(1 (Suppl.)), 257-261. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15239
dc.description.abstract In view of the well-documented medicinal properties of Calotropis procera (CP), the present study was designed to evaluate the neuroprotective effect of the extract. We have prepared a methanolic extract of Calotropis procera and screen varying concentration of CP (20, 30, 40, 50 and 70µg/ml) for the stimulatory potency on neurite outgrowth. The stimulatory effect of CP on neurite outgrowth was assessed in primary hippocampal neurons. Neurite lengths were measured using optika provison analysis software. Neuritogenesis was further analyzed by immunostaining by using specific neuronal marker β III-tubulin. The data show that neurite outgrowth from hippocampal neurons were significantly enhanced in the presence of CP (40µg/ml). The most stimulatory neurite outgrowth effects were appeared after 48hrs incubation of neurons with CP (40µg/ml). These data confirm that CP extract could promote invitro hippocampal neurite outgrowth in a dose-dependent manner. Our results indicate that CP can be used as a healthy dietary supplement for the cognitive functions of the brain. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Neurite outgrowth en_US
dc.subject Calotropis procera en_US
dc.subject Neuroprotective en_US
dc.title Neurite outgrowth properties of Calotropis procera: In search for a neuroprotectant en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account