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Effect of isoespintanol isolated from Oxandra cf. xylopioides against DNA damage of human lymphocytes

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dc.contributor.author Marquez-Fernandez Maria, Elena
dc.contributor.author Munoz-Lasso, Diana Carolina
dc.contributor.author Juan Bautista Lopez
dc.contributor.author Zapata, Karol
dc.contributor.author Mejia, Miguel Angel Puertas
dc.contributor.author Alarcon, Camilo Lopez
dc.contributor.author Rojano, Benjamin Alberto
dc.date.accessioned 2022-12-19T05:31:34Z
dc.date.available 2022-12-19T05:31:34Z
dc.date.issued 2018-09-01
dc.identifier.citation Marquez-Fernandez, M. E., Munoz-Lasso, D. C., Lopez, J. B., Zapata, K., Mejia, M. A. P., Alarcon, C. L., & Rojano, B. A. (2018). Effect of isoespintanol isolated from Oxandra cf. xylopioides against DNA damage of human lymphocytes. Pak. J. Pharm. Sci, 31(5), 1777-1782. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15249
dc.description.abstract Synthetic antioxidants are used in the food and pharmaceutical industry, however, there is concern about their safety; this has prompted the search for new antioxidants that are effective, safe and act at low concentrations. The objective of this study is to evaluate the oxygen radical scavenging capacity and clastogenic effect of the Isoespintanol /2-isopropyl-3,6-dimethyl-5-methylphenol) in DNA of human lymphocyte compared with the BHA (Butylated hydroxyanisole). The oxygen radical scavenging ability was evaluated by methods ORACFL and ORACPGR, genotoxicity was determined by comet assay and data analysis was performed using ANOVA and Duncan test. The results show that the oxygen radical scavenging capacity of the BHA is higher than Isoespintanol, however according to the reactivity concept proposed by Lopez-Alarcon and Lissi, the Isoespintanol it is more reactive than BHA. Furthermore, according to some studies, BHA presented adverse effects on the health of consumers. Comet assay results revealed that at concentrations between 3 and 1620 µM the Isoespintanol don’t show clastogenic effects on DNA. In conclusion, the antioxidant capacity for the BHA is higher than Isoespintanol, but considering reactivity concepts proposed by LopezAlarcon and Lissi, the Isoespintanol is faster to neutralize radicals that the BHA, furthermore, according to the National Institute of Health "BHA" is a human carcinogen. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject DNA damage en_US
dc.subject antioxidants en_US
dc.subject BHA en_US
dc.subject biological products en_US
dc.title Effect of isoespintanol isolated from Oxandra cf. xylopioides against DNA damage of human lymphocytes en_US
dc.type Article en_US


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