PASTIC Dspace Repository

Development and evaluation of immediate release diclofenac sodium suppositories

Show simple item record

dc.contributor.author Tariq Sultan
dc.contributor.author Shaista Hamid
dc.contributor.author Sohail Hassan
dc.contributor.author Kanwal Hussain
dc.contributor.author Ateka Ahmed
dc.contributor.author Lubna Bashir
dc.contributor.author Shazia Naz
dc.contributor.author Tahmina Maqbool
dc.date.accessioned 2022-12-19T05:33:07Z
dc.date.available 2022-12-19T05:33:07Z
dc.date.issued 2018-09-03
dc.identifier.citation Sultan, T., Hamid, S., Hassan, S., Hussain, K., Ahmed, A., Bashir, L., ... & Pak, T. M. (2018). Development and evaluation of immediate release diclofenac sodium suppositories. Pharm. Sci, 31(5), 1791-1795. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15251
dc.description.abstract The objective of present study was to develop and evaluate polyethylene glycol (PEG) based diclofenac sodium suppositories. This study used water soluble PEG bases (1000, 4000 and 6000) in different combinations to formulate suppositories, which were further subjected for their physicochemical properties evaluation such as weight variation, average melting point, content uniformity and disintegration. Dissolution test was used to perform the in vitro release rate studies of the suppositories. The suppository (P3) containing PEG-6000 (50%) and PEG-4000 (50%) exhibited rapid in vitro release rate of diclofenac sodium. Moreover, homogeneous distribution of diclofenac sodium is found in all six formulations. The in vitro release patterns of diclofenac sodium from the marketed Voltral suppository (100mg) and formulated suppositories were also compared and found in standard limits en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Water soluble bases en_US
dc.subject polyethylene glycol en_US
dc.subject suppositories en_US
dc.subject diclofenac sodium en_US
dc.subject in vitro release study en_US
dc.title Development and evaluation of immediate release diclofenac sodium suppositories en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account