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Prunus domestica alters functions of frog’s heart

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dc.contributor.author Talat Ahmed
dc.contributor.author Abida Shaheen
dc.contributor.author Fahad Azam
dc.contributor.author Waseem Safdar
dc.date.accessioned 2022-12-19T05:41:17Z
dc.date.available 2022-12-19T05:41:17Z
dc.date.issued 2018-09-07
dc.identifier.citation Ahmed, T., Shaheen, A., Azam, F., & Safdar, W. (2018). Prunus domestica alters functions of frog's heart. Pakistan journal of pharmaceutical sciences, 31(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15255
dc.description.abstract Prunes could exert cardiovascular protective effects. Trials have demonstrated antihypertensive effects of Prunus domestica. The aim of this study was to find out if prunes could alter cardiac functions that may help understanding the mode of control of hypertension. Changes in rate and contractile force of frogs’ heart were recorded using Power Lab. Effects of prunes’ extracts: aqueous (10, 20, 40%); methanolic, acetonic, ethanolic and chloformic (10%); were evaluated and compared with other drugs. We tested effects of acetylcholine and atropine (10-5), adrenaline, propranolol, verapamil and diltiazem (10-3); NaC1, KCl, CaC12, MgC12 (10% w/v) on frog’s heart alone and with prunes/drugs. All extracts of prunes significantly reduced HR and contractile force. Prunes combined with acetylcholine, propranolol or verapamil significantly enhanced bradycardia; whereas it blocked tachycardia produced by epinephrine, atropine or calcium; moreover prunes blocked the significant increase in HR and cardiac contractility produced by CaCl2; and reduced HR along with MgC12. NaCl and KCl alone or with prunes had non-significant effects on frog’s heart. In conclusion, Prunus domestica plays a key role in modification of intracellular Ca+2 concentration resulting in negative ionotropic and chronotropic effects (similar to cholinergic stimulation and adrenergic or calcium channel blockade) that could lead to hypotensive effects. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Prunus domestica en_US
dc.subject frog’s heart en_US
dc.subject acetylcholine en_US
dc.subject adrenaline en_US
dc.subject calcium en_US
dc.title Prunus domestica alters functions of frog’s heart en_US
dc.type Article en_US


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