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Estimation of simvastatin and cetirizine by RP-LC method: Application to freeze and thaw (FT) stability studies

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dc.contributor.author Naveed, Safila
dc.contributor.author Khan, Usman Ghani
dc.contributor.author Aisha Sana
dc.contributor.author Huma Ali
dc.contributor.author Farya Zafar
dc.contributor.author Fatima Qamar
dc.contributor.author Ghulam Sarwer
dc.contributor.author Sarah Abbas
dc.contributor.author Alam, M Tanweer
dc.contributor.author Shinwari, Muhammad Ibrar
dc.date.accessioned 2022-12-19T05:56:21Z
dc.date.available 2022-12-19T05:56:21Z
dc.date.issued 2018-01-20
dc.identifier.citation Naveed, S., Usmanghani, K., Sana, A., Ali, H., Zafar, F., Qamar, F., ... & Shinwari, M. I. (2018). Estimation of simvastatin and cetirizine by RP-LC method: Application to freeze and thaw (FT) stability studies. Pak. J. Pharm. Sci, 31(1), 137-141. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15263
dc.description.abstract Sensitive, simple, reliable and rapid HPLC technique for the estimation of simvastatin (SMV) and cetirizine has been designed in this study. The chromatographic conditions were set using Shimadzu LC-10 AT VP pump, with UV detector (SPD-10 AV-VP). System integration was performed with CBM-102 (Bus Module). Partitioning of components was attained with pre-packed C-18 column of Purospher Star (5 µm, 250 x 4.6 mm) at ambient conditions. Injected volume of sample was 10 µl. Mobile phase was composed of 50:50 v/v ratio of Acetonitrile/water (pH 3.0 adjusted with ortho-phosphoric acid) having 2 ml/minutes rate of flow. Compounds were detected in UV region at 225 nm. Percent Recovery of simvastatin was observed in the range of 98-102%. All results were found in accept table range of specification. The projected method is consistent, specific, precise, and rapid, that can be employed to quantitate the SMV along with cetirizine HCl. It was estimated by 3 successive cycles of freeze and thaw stability. Results of FT samples were found within accept table limits the method was developed and validated in raw materials, bulk formulations and final drug products en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Simvastatin en_US
dc.subject Cetirizine en_US
dc.subject stability studies en_US
dc.subject HPLC determination. en_US
dc.title Estimation of simvastatin and cetirizine by RP-LC method: Application to freeze and thaw (FT) stability studies en_US
dc.type Article en_US


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