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Antiulcer activity of methanol-chloroform extract of Channa striatus fillet

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dc.contributor.author Azemi, Ahmad Khusairi
dc.contributor.author Abd Rahim, Mohd Hafiz
dc.contributor.author Mamat, Siti Syariah
dc.contributor.author Mat Jais, Abdul Manan
dc.contributor.author Zakaria, Zainul Amiruddin
dc.date.accessioned 2022-12-19T09:39:26Z
dc.date.available 2022-12-19T09:39:26Z
dc.date.issued 2018-01-20
dc.identifier.citation Azemi, A. K., Abd Rahim, M. H., Mamat, S. S., Mat Jais, A. M., & Zakaria, Z. A. (2018). Antiulcer activity of methanol-chloroform extract of Channa striatus fillet. Pakistan journal of pharmaceutical sciences, 31(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15267
dc.description.abstract Channa striatus (Haruan) is Malaysian freshwater fish that is traditionally used to treat ailments related to wound and also ulcers. The aimed of the present study was to determine the mechanisms of anti-ulcer activity of chloroform: methanol extract of C. striatus fillet (CMCS) in rats. The antiulcer profile of CMCS, given orally in the doses of 50, 250 and 500mg/kg, was assessed using the ethanol- and indomethacin-induced gastric ulcer models. The mechanisms of antiulcer of CMCS were determined as follows; i) the antisecretory activity of CMCS was measured using the pyloric ligation rat model, and; ii) the role of nitric oxide (NO) and sulfhydryl compounds in the modulation of CMCS antiulcer activity were determined by pre-treating the rats with L-NAME or NEM, respectively, followed by the pre-treatment of rats with CMCS before subjecting the animals to the ethanol-induced gastric ulcer model. From the results obtained, CMCS exerted significant (P<0.05) antiulcer activity in both models of gastric ulcer wherein the macroscopic and microscopic analysis of the stomach supported the antiulcer claim. With regard to its antisecretory effect, CMCS did not change the volume and pH, but reduce the total acidity only at the lower doses of the gastric juice. Moreover, CMCS demonstrated antiulcer activity was reversed by NEM, but not affected by L-NAME. In conclusion, CMCS shows antiulcer activity that is modulated via its cytoprotective, but not antisecretory effect, and in the presence of sulfhysryl compounds, but not NO. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Channa striatus en_US
dc.subject chloroform en_US
dc.subject methanol extract en_US
dc.subject anti-ulcer activity en_US
dc.subject mechanisms of action en_US
dc.subject cytoprotective. en_US
dc.title Antiulcer activity of methanol-chloroform extract of Channa striatus fillet en_US
dc.type Article en_US


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