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CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITIES OF LEAVES OF ZIZIPHUS MAURITIANA L. NATIVE TO PAKISTAN

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dc.contributor.author AISHA ASHRAF
dc.contributor.author RAJA ADIL SARFRAZ
dc.contributor.author FAROOQ ANWAR
dc.contributor.author SHAUKAT ALI SHAHID
dc.contributor.author KHALID M. ALKHARFY
dc.date.accessioned 2023-01-05T04:29:31Z
dc.date.available 2023-01-05T04:29:31Z
dc.date.issued 2015-03-23
dc.identifier.citation Ashraf, A., Sarfraz, R. A., Anwar, F., Shahid, S. A., & Alkharfy, K. M. (2015). Chemical composition and biological activities of leaves of Ziziphus mauritiana L. native to Pakistan. Pak. J. Bot, 47(1), 367-376. en_US
dc.identifier.issn 2070-3368
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15537
dc.description.abstract Ziziphus mauritiana L., is a fruit tree well known for its nutritional and medicinal benefits. The aim of the current study was to investigate the chemical composition as well as biological (antioxidant, antimicrobial, antitumor and anticancer) attributes of different solvent extracts from the leaves of Ziziphus mauritiana. It was established by colorimetric method that chloroform extract had greater amount of total phenolics (84.69 ± 0.92 μg GAE/mg of extract), while methanol extract contained higher content of total flavonoids (46.94±1.55 µg QE/mg of extract). Meanwhile, methanol extract exhibited higher DPPH free radical scavenging potential (IC50 = 0.11 mg/mL) and antimicrobial (antibacterial and antifungal) activity among others. Overall, E. coli was noted to be the most resistant microbial strain against all the tested extracts. Chloroform extract showed strongest antitumor (IC50 = 70.74µg/mL) and anticancer activity (IC50 values of 27.78 and 18.32 µg/mL against human cancer cell lines U937 and HCT-116, respectively) and significantly inhibited the viability of these cell lines.According to GC-MS analysis methyl stearate (15.59%), plamitic acid (38.55%) and α-linolenic acid (26.45%) were identified as the major components of methanol, chloroform and hexane extracts, respectively in addition to presence of several other bioactives. The results of this study conclude that Z. mauritiana leaves extract with efficient biological activities can be explored for potential uses as antioxidant, antitumor and anticancer agents for pharmaceutical industry. en_US
dc.language.iso en en_US
dc.publisher Karachi: Pakistan Botanical Society en_US
dc.subject Solvent extracts en_US
dc.subject DPPH radical scavengers en_US
dc.subject Flavonoids en_US
dc.subject Phenolics en_US
dc.subject GC-MS en_US
dc.subject Human cancer cell lines en_US
dc.title CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITIES OF LEAVES OF ZIZIPHUS MAURITIANA L. NATIVE TO PAKISTAN en_US
dc.type Article en_US


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