dc.contributor.author |
Zeng, Cheng |
|
dc.contributor.author |
Zheng, Ruifang |
|
dc.contributor.author |
Jiang, Wen |
|
dc.contributor.author |
He, Chenghui |
|
dc.contributor.author |
Li, Jianguang |
|
dc.contributor.author |
Xing, Jianguo |
|
dc.date.accessioned |
2023-01-10T07:10:36Z |
|
dc.date.available |
2023-01-10T07:10:36Z |
|
dc.date.issued |
2018-09-11 |
|
dc.identifier.citation |
Zeng, C., Zheng, R., Jiang, W., He, C., Li, J., & Xing, J. (2018). Chitosan coated chlorogenic acid and rutincomposite phospholipid liposomes: Preparation, characterizations, permeability and pharmacokinetic. Pakistan Journal of Pharmaceutical Sciences. |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/15922 |
|
dc.description.abstract |
In order to research and enhance bioavailability of chlorogenic acid and rutin(CA-R) via the oral route,
chitosan coated composite phospholipid liposomes (C-CPLs) were applied to study on preparation, permeability and pharmacokinetic of C-CA-R-CPLs. TheC-CA-R-CPLs were prepared by the method of ethanol injection. The entrapment efficiency (EE), average particle sizes, polymer disperse index (PDI), zeta potential, shape and in vitro drug release were investigated to characterize physicochemical parameters of C-CA-R-CPLs. The penetration properties from C-CA-R-CPLs were studied through Caco-2 cells model and the pharmacokinetics in Sprague-Dawley (SD) rats were evaluated by rat jugular vein intubation tube. The EE of C-CA-R-CPLs of CA and R was 91.3±2.13% and 92.6±2.44%, particle size of C-CA-R-CPLs was 176.7±2.3 nm, PDI was 0.207±0.014 and zeta potential of 12.61±1.33 mV. CA-RCPLs and C-CA-R-CPLs were spherical or elliptical sphere and the bilayer of the CPL was observed obviously under transmission electron. The C max, t1/2 and AUC0-12 h values of CA and R for groups of C-CA-R-CPLs were significantly increased.In conclusion, TheC-CA-R-CPLs as a novel nano-formulation have potential to be used to enhance the oral
bioavailability of poorlywater-soluble drugs after oral administration. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
en_US |
dc.subject |
Chlorogenic acid |
en_US |
dc.subject |
rutin |
en_US |
dc.subject |
composite phospholipid liposome |
en_US |
dc.subject |
chitosan |
en_US |
dc.subject |
permeability |
en_US |
dc.subject |
pharmacokinetic |
en_US |
dc.title |
Chitosan coated chlorogenic acid and rutincomposite phospholipid liposomes: Preparation, characterizations, permeability and pharmacokinetic |
en_US |
dc.type |
Article |
en_US |